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Triglide Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Triglide (fenofibrate) is used to treat high cholesterol and high triglyceride levels. It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Many people using Triglide do not have serious side effects. It may infrequently cause gallstones and liver problems. If you have severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, tell your doctor.
The dose of Triglide to treat primary hypercholesterolemia or mixed dyslipidemia is 160 mg once daily. Triglide may interact with blood thinners, cyclosporine, or other cholesterol-lowering medicines. Tell your doctor all medications you use. Triglide is not recommended during pregnancy. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
Our Triglide (fenofibrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Triglide in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Stop using fenofibrate and call your doctor at once if you have:
- severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
- pain, swelling, warmth, or redness in one or both legs.
Common side effects may include:
- mild stomach pain;
- back pain;
- headache; or
- runny or stuffy nose.
Read the entire detailed patient monograph for Triglide (Fenofibrate) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Triglide Overview - Patient Information: Side Effects
This medication may infrequently cause gallstones and liver problems. If you notice any of the following unlikely but serious side effects, tell your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.
This drug may infrequently cause muscle problems (which can rarely lead to a very serious condition called rhabdomyolysis). Tell your doctor immediately if you develop any of these symptoms: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), change in the amount of urine.
Rarely, this medication has caused severe lowering of HDL ("good" cholesterol) levels. This is the opposite of what should happen to your HDL levels (paradoxical reaction). Your HDL cholesterol levels should be checked regularly. Keep all of your laboratory appointments.
Tell your doctor immediately if any of these rare but serious side effects occur: easy bleeding/bruising, signs of infection (such as fever, persistent sore throat), unusual tiredness, chest pain, pain/redness/swelling of arms or legs.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Triglide (Fenofibrate)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Triglide FDA Prescribing Information: Side Effects
Clinical Trials Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect rates observed in clinical practice.
Adverse reactions reported by 2% or more of patients treated with fenofibrate (and greater than placebo) during double-blind, placebo-controlled trials are listed in Table 1. Adverse reactions led to discontinuation of treatment in 5.0% of patients treated with fenofibrate and in 3.0% treated with placebo. Increases in liver function tests were the most frequent events, causing discontinuation of fenofibrate treatment in 1.6% of patients in double-blind trials.
Table 1: Adverse Reactions Reported by 2% or More of
Patients Treated with Fenofibrate and Greater than Placebo During the
Double-Blind, Placebo-Controlled Trials
|BODY SYSTEM Adverse Reaction||Fenofibrate* (N=439)||Placebo (N=365)|
|BODY AS A WHOLE|
|METABOLIC AND NUTRITIONAL DISORDERS|
|Abnormal Liver Tests||7.5%**||1.40%|
|Increased Creatine Phosphokinase||3.00%||1.40%|
|* Dosage equivalent to 200 mg
fenofibrate capsules, micronized. Dosage comparable to 160 mg Triglide.
** Significantly different from placebo.
The following adverse reactions have been identified during postapproval use of fenofibrate: myalgia, rhabdomyolysis, pancreatitis, muscle spasms, acute renal failure, hepatitis, cirrhosis, anemia, arthralgia, asthenia, and severely depressed HDL-cholesterol levels. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Read the entire FDA prescribing information for Triglide (Fenofibrate) »
Additional Triglide Information
Triglide - User Reviews
Triglide User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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