Trilisate (Choline Magnesium Trisalicylate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Trilisate

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Osteoarthritis facts

Osteoarthritis is a joint inflammation that results from cartilage degeneration.
Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
The most common symptom of osteoarthritis is pain in the affected joint(s) after repetitive use.
There is no blood test for the diagnosis of osteoarthritis.
The goal of treatment in osteoarthritis is to reduce joint pain and inflammation while improving and maintaining joint function.

What is osteoarthritis?

Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a "cushion" between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common, affecting over 25 million people in the United Stat...

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Trilisate

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

DRUG DESCRIPTION

Trilisate (choline magnesium trisalicylate) ® (choline magnesium trisalicylate) TABLETS/LIQUID

500 mg, 750 mg or 1000 mg salicylate content

TRILISATE (choline magnesium trisalicylate) Tablets/ Liquid are nonsteroidal, anti-inflammatory preparations containing choline magnesium trisalicylate which is freely soluble in water. The absolute structure of choline magnesium trisalicylate is not known at this time. Choline magnesium trisalicylate has a molecular formula of C₂₆H₂₉O₁₀NMg, and a molecular weight of 539.8.

This substance when dissolved in water would appear to form 5 ions (1 choline ion, 1 magnesium ion and 3 salicylate ions).

TRILISATE (choline magnesium trisalicylate) Tablets/ Liquid are available in scored, pale pink 500 mg tablets; in scored, white, film-coated 750 mg tablets, and in scored, red, film-coated 1000 mg tablets. TRILISATE (choline magnesium trisalicylate) Liquid is a cherry cordial-flavored liquid providing 500 mg salicylate content per teaspoonful (5 ml) for oral administration.

Each 500 mg tablet contains 293 mg of choline salicylate combined with 362 mg of magnesium salicylate to provide 500 mg salicylate content.

Each 750 mg tablet contains 440 mg of choline salicylate combined with 544 mg of magnesium salicylate to provide 750 mg salicylate content.

Each 1000 mg tablet contains 587 mg of choline salicylate combined with 725 mg magnesium salicylate to provide 1000 mg salicylate content.

TRILISATE (choline magnesium trisalicylate) Liquid contains 293 mg of choline salicylate combined with 362 mg of magnesium salicylate to provide 500 mg salicylate per teaspoonful (5 ml) in a clear amber, cherry cordial-flavored vehicle.

Inactive Ingredients

Each 500 mg tablet contains: Carboxymethylcellulose sodium, Corn starch, Edetate disodium, FD& C Yellow No. 6, Stearic acid, and other ingredients.

Each 750 mg tablet contains: Carboxymethylcellulose sodium, Edetate disodium, Hydroxypropyl methylcellulose, Polyethylene glycol, Polysorbate 20, Stearic acid, Talc, Titanium dioxide, and other ingredients.

Each 1000 mg tablet contains: Carboxymethylcellulose sodium, Edetate disodium, FD& C Red No. 40, FD& C Yellow No. 6, FD& C Blue No. 2, Hydroxypropyl methylcellulose, Polyethylene glycol, Polysorbate 20, Polysorbate 80, Stearic acid, Talc, Titanium dioxide, and other ingredients.

Each teaspoonful (5 ml) of Liquid contains: Caramel, Carboxymethylcellulose sodium, Edetate disodium, FD& C Yellow No. 6, Glycerin, High fructose corn syrup, Potassium sorbate, Water, and Artificial flavors.

What are the possible side effects of choline magnesium trisalicylate (Choline Magnesium Trisalicylate, Tricosal, Trilisate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;
sudden numbness or weakness, especially on one side of the body;
feeling like you...

Read All Potential Side Effects and See Pictures of Trilisate »

What are the precautions when taking choline magnesium trisalicylate (Trilisate)?

Before taking choline salicylate/magnesium salicylate, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, salsalate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), severe kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, bleeding/clotting...

Read All Potential Precautions of Trilisate »

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.