Trilisate (Choline Magnesium Trisalicylate) Patient Information: How Should I Take the Drug at RxList

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May 27, 2012

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Osteoarthritis facts

Osteoarthritis is a joint inflammation that results from cartilage degeneration.
Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
The most common symptom of osteoarthritis is pain in the affected joint(s) after repetitive use.
There is no blood test for the diagnosis of osteoarthritis.
The goal of treatment in osteoarthritis is to reduce joint pain and inflammation while improving and maintaining joint function.

What is osteoarthritis?

Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a "cushion" between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common, affecting over 25 million people in the United Stat...

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Trilisate Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking choline magnesium trisalicylate (Trilisate)?

Salicylates may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use choline magnesium trisalicylate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Salicylates may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking choline magnesium trisalicylate, especially in older adults.

You should not use this medication if you are allergic to aspirin or to an NSAID (non-steroidal anti-inflammatory drug), or if you have recently used:

cidofovir (Vistide);
ketorolac (Toradol); or
nasal flu vaccine (FluMist).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take this medication:

asthma;
heart disease, high blood pressure, congestive heart failure;
a history of stroke or heart attack;
a stomach ulcer or intestinal bleeding;
a bleeding or blood clotting disorder;
diabetes;
swelling or fluid retention;
anemia (a lack of red blood cells);
liver disease;
kidney disease;
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
nasal polyps; or
if you are dehydrated.

FDA pregnancy category C. Choline magnesium trisalicylate may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. Do not take this medication without telling your doctor if you are pregnant or plan to become pregnant during treatment.

Choline magnesium trisalicylate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Older adults may be more likely to have side effects from choline magnesium trisalicylate.

How should I take choline magnesium trisalicylate (Trilisate)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Choline magnesium trisalicylate may be taken up to 3 times per day. Follow your doctor's instructions.

Take the medicine with a full glass of water.

Take choline magnesium trisalicylate with food, milk, or an antacid if it upsets your stomach.

You may need to take the medicine at bedtime. To prevent stomach upset, take the medicine at least 30 minutes before you lie down.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

You may mix choline magnesium trisalicylate with a small amount of fruit juice to make the medicine taste better. Stir the mixture well and drink all of it right away. Do not save the mixture for later use.

It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not start to improve after 2 weeks of treatment.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using choline magnesium trisalicylate.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using choline magnesium trisalicylate. You may need to stop using the medicine for a short time.

Store choline magnesium trisalicylate at room temperature away from moisture and heat.

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