Brand Names: Choline Magnesium Trisalicylate, Tricosal, Trilisate

Generic Name: choline magnesium trisalicylate (Pronunciation: KOE leen mag NEE see um TRYE sa LIS i late)

• What is choline magnesium trisalicylate (Trilisate)?
• What are the possible side effects of choline magnesium trisalicylate (Trilisate)?
• What is the most important information I should know about choline magnesium trisalicylate (Trilisate)?
• What should I discuss with my healthcare provider before taking choline magnesium trisalicylate (Trilisate)?
• How should I take choline magnesium trisalicylate (Trilisate)?
• What happens if I miss a dose (Trilisate)?
• What happens if I overdose (Trilisate)?
• What should I avoid while taking choline magnesium trisalicylate (Trilisate)?
• What other drugs will affect choline magnesium trisalicylate (Trilisate)?
• Where can I get more information?

What is choline magnesium trisalicylate (Trilisate)?

Choline magnesium trisalicylate is a non-steroidal anti-inflammatory drug (NSAID). This medication is a combination of choline salicylate and magnesium salicylate. Both are in a group of drugs called salicylates (sa-LIS-il-ates). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.

Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

Choline magnesium trisalicylate may also be used for other purposes not listed in this medication guide.

Choline Mg Salicylate 500 mg-SID

oblong, yellow, imprinted with SL 528

Trilisate 750 mg

oblong, white, imprinted with P F, T 750

What are the possible side effects of choline magnesium trisalicylate (Trilisate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

• chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;
• sudden numbness or weakness, especially on one side of the body;
• feeling like you might pass out;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• blood in your urine, urinating more or less than usual;
• hearing problems, ringing in your ears;
• severe stomach pain, ongoing nausea or vomiting;
• swelling, rapid weight gain;
• easy bruising or bleeding, unusual weakness;
• fast or pounding heartbeats; or
• jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• heartburn, upset stomach, diarrhea, constipation;
• dizziness, drowsiness, lack of energy; or
• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about choline magnesium trisalicylate (Trilisate)?

You should not use this medication if you are allergic to aspirin or to an NSAID (non-steroidal anti-inflammatory drug), or if you have recently used cidofovir (Vistide), ketorolac (Toradol), or nasal flu vaccine (FluMist).

Before taking choline magnesium salicylate, tell your doctor if you have asthma, heart disease, high blood pressure, stomach or intestinal bleeding, diabetes, anemia, a bleeding disorder, liver or kidney disease, nasal polyps, a genetic enzyme deficiency, or if you are dehydrated.

Choline magnesium trisalicylate may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use choline magnesium trisalicylate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, severe dizziness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking choline magnesium trisalicylate, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.