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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Trilisate Patient Information Including Side Effects

Brand Names: Choline Magnesium Trisalicylate, Tricosal, Trilisate

Generic Name: choline magnesium trisalicylate (Pronunciation: KOE leen mag NEE see um TRYE sa LIS i late)

What is choline magnesium trisalicylate (Trilisate)?

Choline magnesium trisalicylate is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate.

Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

Choline magnesium trisalicylate may also be used for purposes not listed in this medication guide.

Choline Mg Salicylate 500 mg-SID

oblong, yellow, imprinted with SL 528

Trilisate 750 mg

oblong, white, imprinted with P F, T 750

What are the possible side effects of choline magnesium trisalicylate (Trilisate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using choline magnesium trisalicylate and call your doctor at once if you have a serious side effect such as:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  • sudden numbness or weakness, especially on one side of the body;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • blood in your urine, urinating more or less than usual;
  • hearing problems, ringing in your ears;
  • severe stomach pain, ongoing nausea or vomiting, jaundice (yellowing of the skin or eyes);
  • easy bruising or bleeding, unusual weakness; or
  • fast or pounding heartbeats, feeling like you might pass out.

Less serious side effects may include:

  • heartburn, upset stomach, diarrhea, constipation;
  • dizziness, drowsiness, lack of energy; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Trilisate (choline magnesium trisalicylate) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about choline magnesium trisalicylate (Trilisate)?

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Side Effects Centers

Trilisate - User Reviews

Trilisate User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Trilisate sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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