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TriLyte Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
TriLyte (PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution) is used to clean the bowel before colonoscopy, a barium x-ray, or other intestinal procedures. It is a laxative solution, and also contains potassium, sodium, and other minerals to replace electrolytes that are passed from the body in the stool. This medication is available in generic form. Common side effects include nausea, bloating, or feelings of fullness in the stomach/abdomen. Stomach/abdominal cramps, vomiting, and anal irritation occur less often.
The adult dose of TriLyte when taken orally is at a rate of 240 mL (8 oz.) every 10 minutes, until the rectal effluent is clear or 4 liters are consumed. Pediatric Patients (aged 6 months or greater) should take TriLyte orally at a rate of 25 mL/kg/hour, until the rectal effluent is clear or 4 liters are consumed. Other drugs may interact with TriLyte solution. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, TriLyte should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our TriLyte (PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
TriLyte in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor if you have any of these serious side effects:
- severe stomach pain or bloating;
- no bowel movement within 2 hours after use; or
- gagging, choking, or vomiting.
If you have any of these side effects, you may need to drink the medication more slowly, or stop using it for a short time.
Less serious side effects may include:
- mild stomach cramps, gas, or bloating;
- rectal pain or irritation;
- nausea; or
- passing gas.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for TriLyte (PEG-3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
TriLyte FDA Prescribing Information: Side Effects
Nausea, abdominal fullness and bloating are the most common adverse reactions (occurring in up to 50% of patients) to administration of TriLyte (peg-3350, sodium chloride, sodium bicarbonate and potassium chloride) ® with flavor packs. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis, and (rarely) anaphylactic reaction have been reported which may represent allergic reactions.
Published literature contains isolated reports of serious adverse reactions following the administration of PEG-ELS products in patients over 60 years of age. These adverse events include upper GI bleeding from Mallory-Weiss Tear, esophageal perforation, asystole, sudden dyspnea with pulmonary edema, and "butterfly-like" infiltrate on chest X-ray after vomiting and aspirating PEG.
Read the entire FDA prescribing information for TriLyte (PEG-3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride) »
Additional TriLyte Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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