Trimethoprim

OVERDOSE

Acute

Signs of acute overdosage with trimethoprim (trimethoprim (trimethoprim tablet) tablet) may appear following ingestion of 1 gram or more of the drug and include nausea, vomiting, dizziness, headaches, mental depression, confusion and bone marrow depression (see Chronic subsection).

Treatment consists of gastric lavage and general supportive measures. Acidification of the urine will increase renal elimination of trimethoprim (trimethoprim (trimethoprim tablet) tablet) . Peritoneal dialysis is not effective and hemodialysis is only moderately effective in eliminating the drug.

Chronic

Use of trimethoprim (trimethoprim (trimethoprim tablet) tablet) at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, trimethoprim (trimethoprim (trimethoprim tablet) tablet) should be discontinued and the patient should be given leucovorin; 5 to 15 mg leucovorin daily has been recommended by some investigators.

CONTRAINDICATIONS

Trimethoprim (trimethoprim (trimethoprim tablet) tablet) tablets are contraindicated in individuals hypersensitive to trimethoprim (trimethoprim (trimethoprim tablet) tablet) and in those with documented megaloblastic anemia due to folate deficiency.

Last reviewed on RxList: 9/18/2008
This monograph has been modified to include the generic and brand name in many instances.

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