Trimethoprim

Trimethoprim

Trimethoprim Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Trimethoprim [Brand names: Trimpex (Discontinued Brand), Proloprim (Discontinued Brand), Primsol] is used to treat bacterial infections. Trimethoprim is often combined in a single pill with sulfamethoxazole. It is an antibiotic. This medication is available in generic form. Common side effects include diarrhea, nausea, vomiting, stomach upset, loss of appetite, changes in taste, or headache.

The usual oral adult dosage of Trimethoprim is 100 mg every 12 hours or 200 mg trimethoprim every 24 hours, each for 10 days. Trimethoprim may interact with dofetilide, digoxin, methotrexate, phenytoin, procainamide, and it may decrease the effectiveness of hormonal birth control. Tell your doctor all medications you are taking. Trimethoprim should be used only when prescribed during pregnancy. Trimethoprim passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Our Trimethoprim Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Trimethoprim FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

The adverse effects encountered most often with trimethoprim (trimethoprim (trimethoprim tablet) tablet) were rash and pruritus.

Dermatologic

Rash, pruritus, and phototoxic skin eruptions. At the recommended dosage regimens of 100 mg b.i.d. or 200 mg q.d. each for 10 days, the incidence of rash is 2.9% to 6.7%. In clinical studies which employed high doses of trimethoprim (trimethoprim (trimethoprim tablet) tablet) , an elevated incidence of rash was noted. These rashes were maculopapular, morbilliform, pruritic, and generally mild to moderate, appearing 7 to 14 days after the initiation of therapy.

Hypersensitivity

Rare reports of exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell Syndrome), and anaphylaxis have been received.

Gastrointestinal

Epigastric distress, nausea, vomiting, and glossitis. Elevation of serum transaminase and bilirubin has been noted, but the significance of this finding is unknown. Cholestatic jaundice has been rarely reported.

Hematologic

Thrombocytopenia, leukopenia, neutropenia, megaloblastic anemia, and methemoglobinemia.

Metabolic

Hyperkalemia, hyponatremia.

Neurologic

Aseptic meningitis has been rarely reported.

Miscellaneous

Fever, and increases in BUN and serum creatinine levels.

Read the entire FDA prescribing information for Trimethoprim (Trimethoprim Tablet) »

A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

Related Drugs
Related Supplements
advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations