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It is a contraindication to use Tripedia (diphtheria and tetanus toxoids and acellular pertussis vaccine) vaccine after a serious allergic reaction (eg, anaphylaxis) temporally associated with a previous dose of this vaccine or with any components of this vaccine, including thimerosal and gelatin. Because of the uncertainty as to which component of the vaccine might be responsible, no further vaccination with any of these components should be given. Alternatively, such individuals may be referred to an allergist for evaluation if further immunizations are to be considered.
In addition, the following events are contraindications to administration of any pertussis-containing vaccine, including Tripedia (diphtheria and tetanus toxoids and acellular pertussis vaccine) vaccine.11
· Encephalopathy (eg, coma, decreased level of consciousness, prolonged seizures) within 7 days of administration of a previous dose of a pertussis-containing vaccine that is not attributable to another identifiable cause;
· Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy, or progressive encephalopathy. Pertussis vaccine should not be administered to individuals with such conditions until a treatment regimen has been established and the condition has stabilized.
In instances where the pertussis vaccine component is contraindicated, DT vaccine should be administered for the remaining doses in the vaccination schedule.
This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/8/2006
Additional Tripedia Information
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