Tripedia (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Whooping Cough (Pertussis) »

Whooping cough (pertussis) facts

Whooping cough (pertussis) is an acute, highly contagious respiratory infection that is caused by the bacterium Bordetella pertussis.
Whooping cough commonly affects infants and young children but can be prevented by immunization with pertussis vaccine.
Adults may develop whooping cough as their immunity from childhood vaccines wears off over time.
Clinical symptoms occur in three stages; the characteristic bursts of coughing are observed in the second, or paroxysmal, stage.
Antibiotics can help reduce the severity of the disease when administered early in the course of the disease.
Secondary bacterial pneumonia is the most common complication of whooping cough.

What is whooping cough? What is the history of whooping cough?

Whooping cough is a bacterial upper respiratory infection that leads to episodes of violent coughing. The d...

Read the Whooping Cough (Pertussis) article »

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OVERDOSE

No information provided.

CONTRAINDICATIONS

Hypersensitivity to any component of the vaccine is a contraindication to receipt of Tripedia vaccine (see DESCRIPTION section).¹⁵

It is a contraindication to use Tripedia (diphtheria and tetanus toxoids and acellular pertussis vaccine) vaccine after a serious allergic reaction (eg, anaphylaxis) temporally associated with a previous dose of this vaccine or with any components of this vaccine, including thimerosal and gelatin. Because of the uncertainty as to which component of the vaccine might be responsible, no further vaccination with any of these components should be given. Alternatively, such individuals may be referred to an allergist for evaluation if further immunizations are to be considered.

In addition, the following events are contraindications to administration of any pertussis-containing vaccine, including Tripedia (diphtheria and tetanus toxoids and acellular pertussis vaccine) vaccine.¹¹

· Encephalopathy (eg, coma, decreased level of consciousness, prolonged seizures) within 7 days of administration of a previous dose of a pertussis-containing vaccine that is not attributable to another identifiable cause;

· Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy, or progressive encephalopathy. Pertussis vaccine should not be administered to individuals with such conditions until a treatment regimen has been established and the condition has stabilized.

In instances where the pertussis vaccine component is contraindicated, DT vaccine should be administered for the remaining doses in the vaccination schedule.

REFERENCES

11. CDC. General recommendations on immunization: Recommendations of the ACIP and the American Academy of Family Physicians (AAFP). MMWR 2002;51(RR-2):1-35.

15. CDC. Pertussis vaccination: use of acellular pertussis vaccines among infants and young children. Recommendations of the ACIP. MMWR 1997;46(RR-7):1-25.

Last reviewed on RxList: 6/8/2006
This monograph has been modified to include the generic and brand name in many instances.