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Manifestations of TRISENOX (arsenic trioxide) overdosage include convulsions, muscle weakness and confusion.
If symptoms of TRISENOX (arsenic trioxide) overdosage develop, the injection should be immediately discontinued and chelation therapy should be considered. A conventional protocol for acute arsenic intoxication includes dimercaprol administered at a dose of 3 mg/kg intramuscularly every 4 hours until immediate life-threatening toxicity has subsided. Thereafter, penicillamine at a dose of 250 mg orally, up to a maximum frequency of four times per day ( ≤ 1 g per day), may be given.
TRISENOX is contraindicated in patients who are hypersensitive to arsenic.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 3/6/2015
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