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home > drugs a-z list > trisenox (arsenic trioxide injection) drug center > trisenox (arsenic trioxide injection) drug - overdosage and contraindications
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Leukemia facts
- Leukemia is a cancer of the blood cells.
- While the exact cause(s) of leukemia is not known, risk factors have been identified.
- Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
- People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
- The diagnosis of leukemia is supported by findings of the
medical history and examination, and examining blood
and bone marrow samples under a microscope.
- Tre...
Trisenox
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OVERDOSE
If symptoms suggestive of serious acute arsenic toxicity (e.g., convulsions, muscle weakness and confusion) appear, TRISENOX (arsenic trioxide) injection should be immediately discontinued and chelation therapy should be considered. A conventional protocol for acute arsenic intoxication includes dimercaprol administered at a dose of 3 mg/kg intramuscularly every 4 hours until immediate life-threatening toxicity has subsided. Thereafter, penicillamine at a dose of 250 mg orally, up to a maximum frequency of four times per day ( ≤ 1 g per day), may be given.
CONTRAINDICATIONS
TRISENOX (arsenic trioxide injection) is contraindicated in patients who are hypersensitive to arsenic.
Last reviewed on RxList: 8/13/2010
This monograph has been modified to include the generic and brand name in many instances.
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