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If symptoms suggestive of serious acute arsenic toxicity (e.g., convulsions, muscle weakness and confusion) appear, TRISENOX (arsenic trioxide) injection should be immediately discontinued and chelation therapy should be considered. A conventional protocol for acute arsenic intoxication includes dimercaprol administered at a dose of 3 mg/kg intramuscularly every 4 hours until immediate life-threatening toxicity has subsided. Thereafter, penicillamine at a dose of 250 mg orally, up to a maximum frequency of four times per day ( ≤ 1 g per day), may be given.
TRISENOX (arsenic trioxide injection) is contraindicated in patients who are hypersensitive to arsenic.
Last reviewed on RxList: 8/13/2010
This monograph has been modified to include the generic and brand name in many instances.
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