June 26, 2016
Recommended Topic Related To:

Tritec

"VANCOUVER, British Columbia ” There is a small but statistically significant increased risk for acute pancreatitis among the dipeptidyl peptidase-4 (DPP-4) inhibitor class of glucose-lowering agents used in type 2 diabetes treatment, a new meta-a"...

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Tritec

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Overdosage
Contraindications

OVERDOSE

There has been limited experience with overdosage. Adverse events related to overdosage with ranitidine are usually reversible, nonspecific, and non- life threatening and result in no adverse sequelae. Although not seen in clinical trials with TRITEC (ranitidine bismuth citrate) , bismuth intoxication from prolonged overdosage or deliberate self- poisoning can result in neurotoxicity and nephrotoxicity and possibly other symptoms seen with the use of soluble bismuth compounds. In the event of an overdose or suspected bismuth toxicity, measures should be employed to remove unabsorbed material from the gastrointestinal tract, and symptom monitoring and other supportive therapy should be employed, if indicated.

Single oral doses of ranitidine bismuth citrate at 3,000 and 4,000 mg/ kg in male and female mice, respectively (approximately 15 to 20 times the recommended human dose based on body surface area), and at 2,000 and 3,000 mg/ kg in male and female rats, respectively, (approximately 20 to 30 times the recommended human dose based on body surface area) were lethal. Symptoms of acute toxicity were piloerection, tremors, hunched posture, rapid respiration, and decreased activity.

CONTRAINDICATIONS

TRITEC (ranitidine bismuth citrate) is contraindicated in patients known to have hypersensitivity to ranitidine bismuth citrate or any of its ingredients.

For information on clarithromycin contraindications, see clarithromycin package insert.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004

Overdosage
Contraindications

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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