December 1, 2015
Recommended Topic Related To:


"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended 150 mg lamivudine/300 mg raltegravir (Dutrebis, Merck Sharp & Dohme Limited) for the treatment of HIV 1 infection in adults, adolesce"...




There is no known specific treatment for overdose with TRIZIVIR. If overdose occurs, the patient should be monitored and standard supportive treatment applied as required.


It is not known whether abacavir can be removed by peritoneal dialysis or hemodialysis.


Because a negligible amount of lamivudine was removed via (4-hour) hemodialysis, continuous ambulatory peritoneal dialysis, and automated peritoneal dialysis, it is not known if continuous hemodialysis would provide clinical benefit in a lamivudine overdose event.


Acute overdoses of zidovudine have been reported in pediatric patients and adults. These involved exposures up to 50 grams. No specific symptoms or signs have been identified following acute overdosage with zidovudine apart from those listed as adverse events such as fatigue, headache, vomiting, and occasional reports of hematological disturbances. Patients recovered without permanent sequelae. Hemodialysis and peritoneal dialysis appear to have a negligible effect on the removal of zidovudine, while elimination of its primary metabolite, 3'azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine (GZDV), is enhanced.


TRIZIVIR is contraindicated in patients:

  • who have the HLA-B*5701 allele [see WARNINGS AND PRECAUTIONS].
  • with prior hypersensitivity reaction to abacavir [see WARNINGS AND PRECAUTIONS], lamivudine, or zidovudine.
  • with moderate or severe hepatic impairment [see Use in Specific Populations].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 10/23/2015


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