Trizivir (Abacavir Sulfate, Lamivudine, and Zidovudine) Drug Information: Overdosage and Contraindications

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May 27, 2012

Trizivir

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OVERDOSE

Abacavir

There is no known antidote for abacavir. It is not known whether abacavir can be removed by peritoneal dialysis or hemodialysis.

Lamivudine

One case of an adult ingesting 6 grams of lamivudine was reported; there were no clinical signs or symptoms noted and hematologic tests remained normal. It is not known whether lamivudine can be removed by peritoneal dialysis or hemodialysis.

Zidovudine

Acute overdoses of zidovudine have been reported in pediatric patients and adults. These involved exposures up to 50 grams. The only consistent findings were nausea and vomiting. Other reported occurrences included headache, dizziness, drowsiness, lethargy, and confusion. Hematologic changes were transient. All patients recovered. Hemodialysis and peritoneal dialysis appear to have a negligible effect on the removal of zidovudine, while elimination of its primary metabolite, 3'-azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine (GZDV), is enhanced.

CONTRAINDICATIONS

TRIZIVIR Tablets are contraindicated in patients with:

previously demonstrated hypersensitivity to abacavir or any other component of the product. NEVER restart TRIZIVIR or any other abacavir-containing product following a hypersensitivity reaction to abacavir, regardless of HLA-B*5701 status [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS].
hepatic impairment [see Use In Specific Populations].

Last reviewed on RxList: 12/21/2011
This monograph has been modified to include the generic and brand name in many instances.