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Overdoses of topiramate resulted in signs and symptoms which included convulsions, drowsiness, speech disturbance, blurred vision, diplopia, mentation impaired, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after polydrug overdoses involving topiramate.
Topiramate overdose has resulted in severe metabolic acidosis [see WARNINGS AND PRECAUTIONS].
A patient who ingested a dose between 96 g and 110 g of topiramate was admitted to hospital with coma lasting 20 to 24 hours followed by full recovery after 3 to 4 days.
Similar signs, symptoms, and clinical consequences are expected to occur with overdosage of Trokendi XR™. Therefore, in acute Trokendi XR™ overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb topiramate in vitro. Treatment should be appropriately supportive. Hemodialysis is an effective means of removing topiramate from the body.
Trokendi XR™ is contraindicated in patients:
- With recent alcohol use (i.e., within 6 hours prior to and 6 hours after Trokendi XR™ use) [see WARNINGS AND PRECAUTIONS]
- With metabolic acidosis who are taking concomitant metformin [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS]
Last reviewed on RxList: 9/9/2013
This monograph has been modified to include the generic and brand name in many instances.
Additional Trokendi XR Information
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