TrophAmine (Amino Acids) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

May 27, 2012

TrophAmine

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TrophAmine®
(amino acid) Injections

Protect from light until use.

TrophAmine (6% and 10% Amino Acid Injections) are sterile, nonpyrogenic, hypertonic solutions containing crystalline amino acids.

All amino acids designated USP are the “L”-isomer with the exception of Glycine USP which does not have an isomer.

Each 100 mL contains:

Essential Amino Acids	6%	10%
Isoleucine USP	0.49 g	0.82 g
Leucine USP	0.84 g	1.4 g
Lysine	0.49 g	0.82 g
(added as Lysine Acetate USP	0.69 g	1.2 g)
Methionine USP	0.20 g	0.34 g
Phenylalanine USP	0.29 g	0.48 g
Threonine USP	0.25 g	0.42 g
Tryptophan USP	0.12 g	0.20 g
Valine USP	0.47 g	0.78 g
Cysteine	< 0.014 g	< 0.016 g
(as Cysteine HCI•H₂O USP	< 0.020 g	< 0.024 g
Histidine USP¹	0.29 g	0.48 g
Tyrosine¹	0.14 g	0.24 g
(added as Tyrosine USP	0.044 g	0.044 g
and N-Acetyl-L-Tyrosine	0.12 g	0.24 g)
*Nonessential Amino Acids*
Alanine USP	0.32 g	0.54 g
Arginine USP	0.73 g	1.2 g
Proline USP	0.41 g	0.68 g
Serine USP	0.23 g	0.38 g
Glycine USP	0.22 g	0.36 g
L-Aspartic Acid	0.19 g	0.32 g
L-Glutamic Acid	0.30 g	0.50 g
Taurine^2,3	0.015 g	0.025 g
Sodium Metabisulfite NF (as an antioxidant)	< 0.050 g	< 0.050 g
Water for Injection USP pH adjusted with Glacial Acetic Acid USP pH: 5.5 (5.0-6.0)	qs	qs
Calc. Osmolarity (mOsmol/liter)	525	875
Total Amino Acids (grams/liter)	60	100
Total Nitrogen (grams/liter)	9.3	15.5
Protein Equivalent (grams/liter)	58	97
Electrolytes (mEq/liter)
Sodium	5 5
*Acetate (CH₃COO^–)	54.4	97
Chloride	< 3	< 3
*Provided as acetic acid and Iysine acetate. ¹ Holt LE, Snyderman SE: The amino acid requirements of infants. JAMA 1961; 175(2):124-127. ² Rigo J, Senterre J: Is taurine essential for the neonates? Biol Neonate 1977; 32:73-76. ³ Gaull G, Sturman JA, Räihä NCR: Development of mammalian sulfur metabolism: Absence of cystothionase in human fetal tissues. Pediatr Res 1972; 6:538-547.