Trusopt (Dorzolamide Hydrochloride Ophthalmic Solution) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

Pill Identifier Search

February 10, 2012

Trusopt

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

Read the Glaucoma article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
next »

Trusopt User Reviews >>

Trusopt

Eye Diseases and Conditions Slideshow Pictures

Pink Eye Slideshow Pictures

Cataracts Slideshow Pictures

font size

TRUSOPT®
(dorzolamide hydrochloride) Sterile Ophthalmic Solution 2%

DRUG DESCRIPTION

TRUSOPT (dorzolamide hydrochloride ophthalmic solution) is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.

Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is

α 25° (C=1, water) = ~ -17°.
405

Its empirical formula is C₁₀H₁₆N₂O₄S₃•HCl and its structural formula is:

TRUSOPT®
(dorzolamide hydrochloride) Structural Formula Illustration

Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

TRUSOPT (dorzolamide hydrochloride ophthalmic solution) Sterile Ophthalmic Solution is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of TRUSOPT 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.

What are the possible side effects of dorzolamide ophthalmic (Trusopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, pain, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache with a severe blistering, peeling, and...

Read All Potential Side Effects and See Pictures of Trusopt »

What are the precautions when taking dorzolamide hydrochloride ophthalmic solution (Trusopt)?

Before using dorzolamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as the preservative benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, kidney stones, liver disease.

If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of dorzolamide. You may be advised to start using a new bottle.

Your vision may be temporarily blurred or unstable after applying this drug. Do not drive, use machinery, or...

Read All Potential Precautions of Trusopt »

Last reviewed on RxList: 7/20/2010
This monograph has been modified to include the generic and brand name in many instances.