Dr. Schiffman received his B.S. degree with High Honors in biology from Hobart College in 1976. He then moved to Chicago where he studied biochemistry at the University of Illinois, Chicago Circle. He attended Rush Medical College where he received his M.D. degree in 1982 and was elected to the Alpha Omega Alpha Medical Honor Society. He completed his Internal Medicine internship and residency at the University of California, Irvine.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Tuberculosis (TB) is an infection, primarily in the lungs (a pneumonia),
caused by bacteria called Mycobacterium tuberculosis. It is spread usually from
person to person by breathing infected air during close contact.
TB can remain in an inactive (dormant) state for years without causing
symptoms or spreading to other people.
When the immune system of a patient with dormant TB is weakened, the TB can
become active (reactivate) and cause infection in the lungs or other parts of
the body.
The risk factors for acquiring TB include close-contact situations, alcohol
and IV drug abuse, and certain diseases (for
example, diabetes, cancer, and
HIV) and
occupations (for example, health-care workers).
The diagnosis of TB involves
skin tests,
chest X-rays, sputum analysis
(smear and culture), and PCR tests to detect the genetic material of the
causative bacteria.
Inactive tuberculosis may be treated with an antibiotic, isoniazid (INH),
to prevent the TB infection from becoming active.
Active TB is treated, usually successfully, with INH in combination with
one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol),
pyrazinamide, and
streptomycin.
Drug-resistant TB is a serious, as yet unsolved, public-health problem, especially in Southeast Asia, the countries of the former Soviet Union, Africa, and in prison populations. Poor patient compliance, lack of detection of resistant strains, and unavailable therapy are key reasons for the
development of drug-resistant TB.
The occurrence of HIV has been responsible for an increased frequency of
tuberculosis. Control of HIV in the future, however, should substantially
decrease the frequency of TB.
What is tuberculosis?
Tuberculosis (TB) is an infectious disease caused by bacteria whose scientific name is Mycobacterium tuberculosis. It was first isolated in 1882 by a German physician named Robert Koch who received the Nobel
Prize for this discovery. TB most commonly affects the lungs but also can involve almost any organ of the body. Many years ago, this disease was referred to as "consumption" because without effective treatment, these patients often would waste away. Today, of course, tuberculosis usually can be treated successfully with antibiotics.
There is also a group of organisms referred to as atypical tuberculosis. These involve other types of bacteria that are in the
Mycobacterium family. Often, these organisms do not cause disease and are referred to as "colonizers" because they simply live alongside other bacteria in our bodies without causing damage. At times, these bacteria can cause an infection that is sometimes clinically like typical tuberculosis. When these atypical mycobacteria cause infection, they are often very difficult to cure. Often, drug therapy for these organisms must be administered for
one and a half to two years and requires multiple medications.
How does a person get TB?
A person can become infected with tuberculosis bacteria when he or she
inhales minute particles of infected
sputum from the air. The bacteria get into
the air when someone who has a tuberculosis lung infection coughs, sneezes,
shouts, or spits (which is common in some cultures). People who are nearby can
then possibly breathe the bacteria into their lungs. You don't get TB by just
touching the clothes or shaking the hands of someone who is infected.
Tuberculosis is spread (transmitted) primarily from person to person by
breathing infected air during close contact.
There is a form of atypical tuberculosis, however, that is transmitted by drinking unpasteurized milk. Related bacteria, called Mycobacterium bovis, cause this form of TB. Previously, this type of bacteria was a major cause of TB in children, but it rarely causes TB now since most milk is pasteurized (undergoes a heating process that kills the bacteria).