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Tussionex® Pennkinetic®
(hydrocodone polistirex and chlorpheniramine polistirex) Extended-Release Suspension CII


Each 5 mL of TUSSIONEX Pennkinetic Extended-Release Suspension contains hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate and chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate. Hydrocodone is a centrally-acting narcotic antitussive. Chlorpheniramine is an antihistamine. TUSSIONEX Pennkinetic Extended-Release Suspension is for oral use only.

Hydrocodone Polistirex

Sulfonated styrene-divinylbenzene copolymer complex with 4,5α-epoxy-3-methoxy-17methylmorphinan-6-one.

Hydrocodone Polistirex - Structural Formula Illustration

Chlorpheniramine Polistirex

Sulfonated styrene-divinylbenzene copolymer complex with 2-[p-chloro-α-[2(dimethylamino)ethyl]-benzyl]pyridine.

Chlorpheniramine Polistirex - Structural Formula Illustration

Inactive Ingredients

Ascorbic acid, D&C Yellow No. 10, ethylcellulose, FD&C Yellow No. 6, flavor, high fructose corn syrup, methylparaben, polyethylene glycol 3350, polysorbate 80, pregelatinized starch, propylene glycol, propylparaben, purified water, sucrose, vegetable oil, xanthan gum.

What are the possible side effects of chlorpheniramine and hydrocodone (HyTan, Novasus, S-T Forte 2, TussiCaps, Tussionex PennKinetic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • weak or shallow breathing;
  • chest tightness;
  • painful urination;
  • urinating less than usual or not at all; or
  • confusion, hallucinations, or unusual behavior.

Less serious side effects may include:

  • dizziness,...

Read All Potential Side Effects and See Pictures of Tussionex »

What are the precautions when taking hydrocodone and chlorpheniramine (Tussionex)?

Before taking this product, tell your doctor or pharmacist if you are allergic to hydrocodone or chlorpheniramine; or to dexchlorpheniramine; or to hydromorphone; or if you have any other allergies. This product may contain inactive ingredients (including sulfites such as sodium metabisulfite), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, croup, sleep apnea, chronic obstructive pulmonary disease-COPD), brain disorders (such as seizures, head injury, tumor), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), glaucoma (narrow-angle), difficulty...

Read All Potential Precautions of Tussionex »

Last reviewed on RxList: 4/21/2015
This monograph has been modified to include the generic and brand name in many instances.

Tussionex - User Reviews

Tussionex User Reviews

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