"By Matt McMillen
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Tussionex Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Tussionex (chlorpheniramine and hydrocodone) is a combination antihistamine/antitussive drug prescribed for symptomatically managing cold and allergy symptoms. Common side effects of Tussionex include lightheadedness, dizziness, drowsiness, trouble concentrating, mood changes, anxiety, blurred vision, constipation, nausea, vomiting, loss of appetite, dry mouth or throat, sweating, itching or skin rash, and disturbed coordination. Contact your doctor if you have serious side effects of Tussionex including shallow breathing, chest tightness, painful urination, confusion, hallucinations, or unusual behavior.
Tussionex usual dose is 5 ml twice a day. Drug interactions include benzodiazepines (for example, Valium [Diazepam]), tricyclic antidepressants (for example, Elavil [amitriptyline]) and anticholinergic medications (for example, Bentyl [dicyclomine]). Tussionex should not be used during pregnancy as it may cause adverse effects in the fetus unless the potential benefit outweighs the potential unknown risk to the fetus. Tussionex is secreted in human breast milk and may cause adverse effects in the new born.
Our Tussionex Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. articles.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Tussionex in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- weak or shallow breathing;
- chest tightness;
- painful urination;
- urinating less than usual or not at all; or
- confusion, hallucinations, or unusual behavior.
Less serious side effects may include:
- dizziness, drowsiness, trouble concentrating;
- mood changes, anxiety;
- blurred vision;
- constipation, nausea, vomiting, loss of appetite;
- dry mouth or throat;
- sweating; or
- mild itching or skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Tussionex (Hydrocodone and Chlorpheniramine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Tussionex Overview - Patient Information: Side Effects
To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. This medication can dry up and thicken mucus in your lungs, making it more difficult to breathe and clear your lungs. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor.
To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, agitation, confusion, hallucinations), stomach/abdominal pain, difficulty urinating, fast/slow/irregular heartbeat.
Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, fainting, unusual drowsiness/difficulty waking up, seizures.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Tussionex (Hydrocodone and Chlorpheniramine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Tussionex FDA Prescribing Information: Side Effects
Nausea and vomiting may occur; they are more frequent in ambulatory than in recumbent patients. Prolonged administration of TUSSIONEX Pennkinetic Extended-Release Suspension may produce constipation.
General Disorders and Administration Site Conditions
Nervous System Disorders
Renal and Urinary Disorders
Ureteral spasm, spasm of vesical sphincters, and urinary retention have been reported with opiates.
Respiratory, Thoracic and Mediastinal Disorders
TUSSIONEX Pennkinetic Extended-Release Suspension may produce dose-related respiratory depression by acting directly on brain stem respiratory centers (see OVERDOSAGE). Use of TUSSIONEX Pennkinetic Extended-Release Suspension in children less than 6 years of age has been associated with fatal respiratory depression. Overdose with TUSSIONEX Pennkinetic Extended-Release Suspension in children 6 years of age and older, in adolescents, and in adults has been associated with fatal respiratory depression.
Skin and Subcutaneous Tissue Disorders
Drug Abuse And Dependence
TUSSIONEX Pennkinetic Extended-Release Suspension is a Schedule II narcotic. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of narcotics; therefore, TUSSIONEX Pennkinetic Extended-Release Suspension should be prescribed and administered with caution. However, psychic dependence is unlikely to develop when TUSSIONEX Pennkinetic Extended-Release Suspension is used for a short time for the treatment of cough. Physical dependence, the condition in which continued administration of the drug is required to prevent the appearance of a withdrawal syndrome, assumes clinically significant proportions only after several weeks of continued oral narcotic use, although some mild degree of physical dependence may develop after a few days of narcotic therapy.
Read the entire FDA prescribing information for Tussionex (Hydrocodone and Chlorpheniramine)
Additional Tussionex Information
Tussionex - User Reviews
Tussionex User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Allergies & Asthma
Improve treatments & prevent attacks.