Tygacil (Tigecycline) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Tygacil

E. Coli (0157:H7) »

E. coli 0157:H7 Facts

E. coli 0157:H7 is a gram-negative bacterium that can produce a bloody diarrhea due to toxins it secretes when it infects human intestinal tracts.
The symptoms of E. coli 0157:H7 infection may include a low fever, nausea, vomiting, stomach cramps, and bloody diarrhea.
E. coli 0157:H7 is notorious because it can cause additional complications in children and the elderly; renal failure, anemia, and dehydration especially for children (termed HUS or Hemolytic-uremic syndrome) and spontaneous bleeding, organ failures, and mental changes in the elderly (termed TTP or thrombotic thrombocytopenic purpura). Some of these patients develop disabilities or die.
Diagnosis is definitively made when E. coli 0157:H7 is isolated, usually from the patient's stool, and identified as serotype 0157 by immunologic tests.
Most E. coli 0157:H7 infections resolve s...

Read the E. Coli (0157:H7) article »

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PATIENT INFORMATION

Patients should be counseled that antibacterial drugs including TYGACIL (tigecycline) should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When TYGACIL (tigecycline) is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by TYGACIL (tigecycline) or other antibacterial drugs in the future.
Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

This product's label may have been updated. For current package insert and further product information, please visit www.wyeth.com or call our medical communications department toll-free at 1-800-934-5556.

Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.