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home > drugs a-z list > tygacil (tigecycline) drug center > tygacil (tigecycline) drug - overdosage and contraindications
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Tygacil
E. coli 0157:H7 Facts
- E. coli 0157:H7 is a gram-negative bacterium that can produce a bloody diarrhea due to toxins it secretes when it infects human intestinal tracts.
- The symptoms of E. coli 0157:H7 infection may include a low fever, nausea, vomiting, stomach cramps, and bloody diarrhea.
- E. coli 0157:H7 is notorious because it can cause additional complications in children and the elderly; renal failure, anemia, and dehydration especially for children (termed HUS or Hemolytic-uremic syndrome) and spontaneous bleeding, organ failures, and mental changes in the elderly (termed TTP or thrombotic thrombocytopenic purpura). Some of these patients develop disabilities or die.
- Diagnosis is definitively made when E. coli 0157:H7 is isolated, usually from the patient's stool, and identified as serotype 0157 by immunologic tests.
- Most E. coli 0157:H7 infections resolve s...
Tygacil
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OVERDOSE
No specific information is available on the treatment of overdosage with tigecycline. Intravenous administration of TYGACIL (tigecycline) at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting. In single-dose intravenous toxicity studies conducted with tigecycline in mice, the estimated median lethal dose (LD50) was 124 mg/kg in males and 98 mg/kg in females. In rats, the estimated LD50 was 106 mg/kg for both sexes. Tigecycline is not removed in significant quantities by hemodialysis.
CONTRAINDICATIONS
TYGACIL (tigecycline) is contraindicated for use in patients who have known hypersensitivity to tigecycline.
Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.
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