"Leptospirosis is a disease caused by bacteria. These bacteria are carried in the urine of infected animals. If an infected animal urinates in a body of fresh water (e.g., lake, river, stream) or soil, the disease can live there for weeks to month"...
No specific information is available on the treatment of overdosage with tigecycline. Intravenous administration of TYGACIL at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting. In single-dose intravenous toxicity studies conducted with tigecycline in mice, the estimated median lethal dose (LD50) was 124 mg/kg in males and 98 mg/kg in females. In rats, the estimated LD50 was 106 mg/kg for both sexes. Tigecycline is not removed in significant quantities by hemodialysis.
TYGACIL is contraindicated for use in patients who have known hypersensitivity to tigecycline.
Last reviewed on RxList: 10/10/2013
This monograph has been modified to include the generic and brand name in many instances.
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