Tygacil
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Tygacil
OVERDOSE
No specific information is available on the treatment of overdosage with tigecycline. Intravenous administration of TYGACIL (tigecycline) at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting. In single-dose intravenous toxicity studies conducted with tigecycline in mice, the estimated median lethal dose (LD50) was 124 mg/kg in males and 98 mg/kg in females. In rats, the estimated LD50 was 106 mg/kg for both sexes. Tigecycline is not removed in significant quantities by hemodialysis.
CONTRAINDICATIONS
TYGACIL (tigecycline) is contraindicated for use in patients who have known hypersensitivity to tigecycline.
Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.
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