"According to the World Health Organization, in 2010, malaria caused an estimated 219 million illnesses and 660,000 deaths, mostly children under 5 years old in Africa. These numbers represent a 25% decrease in malaria deaths globally and a 33% re"...
No specific information is available on the treatment of overdosage with tigecycline. Intravenous administration of TYGACIL (tigecycline) at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting. In single-dose intravenous toxicity studies conducted with tigecycline in mice, the estimated median lethal dose (LD50) was 124 mg/kg in males and 98 mg/kg in females. In rats, the estimated LD50 was 106 mg/kg for both sexes. Tigecycline is not removed in significant quantities by hemodialysis.
TYGACIL (tigecycline) is contraindicated for use in patients who have known hypersensitivity to tigecycline.
Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.
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