"The U.S. Food and Drug Administration today granted accelerated approval to Perjeta (pertuzumab) as part of a complete treatment regimen for patients with early stage breast cancer before surgery (neoadjuvant setting). Perjeta is the first FDA-ap"...
Tykerb Patient Information including How Should I Take
In this Article
- What is lapatinib (Tykerb)?
- What are the possible side effects of lapatinib (Tykerb)?
- What is the most important information I should know about lapatinib (Tykerb)?
- What should I discuss with my health care provider before taking lapatinib (Tykerb)?
- How should I take lapatinib (Tykerb)?
- What happens if I miss a dose (Tykerb)?
- What happens if I overdose (Tykerb)?
- What should I avoid while taking lapatinib (Tykerb)?
- What other drugs will affect lapatinib (Tykerb)?
- Where can I get more information?
What should I discuss with my health care provider before taking lapatinib (Tykerb)?
You should not use lapatinib if you are allergic to it.
To make sure you can safely take lapatinib, tell your doctor if you have any of these other conditions:
- heart disease;
- liver disease;
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
- a personal or family history of "Long QT syndrome."
FDA pregnancy category D. Do not use lapatinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether lapatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking this medication.
How should I take lapatinib (Tykerb)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. Be sure to also read the medication guide or patient instructions for capecitabine (Xeloda) or letrozole (Femara).
Take lapatinib on an empty stomach, at least 1 hour before or 1 hour after a meal.
The usual dose of lapatinib is equal to 5 or 6 tablets given at one time. The number of tablets you take will depend on your condition and whether you are also taking capecitabine (Xeloda) or letrozole (Femara).
Do not crush a lapatinib tablet. Swallow the pill whole. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly.
You may swallow each lapatinib tablet one at a time, but take the entire dose (all 5 or 6 tablets) at the same time each day.
Lapatinib is usually taken together with capecitabine (Xeloda) in a 21-day cycle. Lapatinib is given once daily for all 21 days in a row, and capecitabine is given twice daily for only the first 14 days of the cycle. This 21-day cycle is then repeated until your doctor decides that lapatinib is no longer an appropriate treatment for your condition. Follow your doctor's instructions.
Capecitabine (Xeloda) must be taken with food or within 30 minutes of eating.
Lapatinib is usually taken together with letrozole (Femara) daily for as long as you continue to take letrozole.
Take lapatinib for the full prescribed length of time. This medication is usually continued unless your condition gets worse or you have serious side effects.
Your heart function will need to be checked before you start treatment with lapatinib. To be sure this medication is not causing harmful effects, your liver function will need to be checked every 4 to 6 weeks. Visit your doctor regularly.
Store lapatinib at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Additional Tykerb Information
- Tykerb Drug Interactions Center: lapatinib oral
- Tykerb Side Effects Center
- Tykerb Overview including Precautions
- Tykerb FDA Approved Prescribing Information including Dosage
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