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Tylenol-Codeine

Last reviewed on RxList: 11/22/2010
Tylenol-Codeine Side Effects Center

Last reviewed on RxList 9/9/2016

Tylenol with Codeine (acetaminophen and codeine phosphate) is a combination of a narcotic pain reliever and a non-salicylate analgesic (pain reliever) and antipyretic (fever reducer) used to relieve moderate to severe pain. Tylenol with Codeine is available in generic form. Common side effects of Tylenol with Codeine include:

Tell your doctor if you experience unlikely but serious side effects of Tylenol with Codeine including mental/mood changes, severe stomach/abdominal pain, or difficulty urinating.

The usual adult dosage of Tylenol with Codeine is 15 mg to 60 mg codeine, and 300 mg to 1000 mg acetaminophen. Doses may be repeated up to every 4 hours. Tylenol with Codeine may interact with glycopyrrolate, mepenzolate, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bladder or urinary medications, bronchodilators, or irritable bowel medications. Tell your doctor all medications you use. During pregnancy, Tylenol with Codeine should be used only when prescribed. Using it near the expected delivery date is not recommended because of potential harm to the fetus. Babies born to mothers who have used this medication may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. If you notice these symptoms in your newborn, tell the doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding. Codeine may be habit-forming. Stopping this medication abruptly may cause withdrawal symptoms.

Our Tylenol with Codeine (acetaminophen and codeine phosphate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tylenol-Codeine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek emergency medical attention if a child taking this medication has any of the following life-threatening side effects: noisy breathing, sighing, slow breathing with long pauses between breaths; being unusually sleepy or hard to wake up; blue colored lips.

Call your doctor at once if you have any of these serious side effects:

  • shallow breathing, slow heartbeat;
  • feeling light-headed, fainting;
  • confusion, unusual thoughts or behavior;
  • seizure (convulsions);
  • easy bruising or bleeding; or
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects include:

  • feeling dizzy or drowsy;
  • mild nausea, vomiting, upset stomach, constipation;
  • headache;
  • blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tylenol-Codeine (Acetaminophen and Codeine)

Tylenol-Codeine Professional Information

SIDE EFFECTS

The most frequently observed adverse reactions include drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea and vomiting. These effects seem to be more prominent in ambulatory than in non-ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down.

Other adverse reactions include allergic reactions, euphoria, dysphoria, constipation, abdominal pain, pruritus, rash, thrombocytopenia, and agranulocytosis.

At higher doses, codeine has most of the disadvantages of morphine including respiratory depression.

Drug Abuse And Dependence

Controlled Substance

TYLENOL® with Codeine (acetaminophen and codeine phosphate) tablets are classified as a Schedule III controlled substance.

Abuse and Dependence

Codeine can produce drug dependence of the morphine type and, therefore, has the potential for being abused. Psychological dependence, physical dependence, and tolerance may develop upon repeated administration and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic medications.

Read the entire FDA prescribing information for Tylenol-Codeine (Acetaminophen and Codeine)

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