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Tyvaso is a sterile formulation of treprostinil intended for administration by oral inhalation using the Optineb-ir device. Tyvaso (treprostinil inhalation solution) is supplied in 2.9 mL low density polyethylene (LDPE) ampules, containing 1.74 mg treprostinil (0.6 mg/mL). Each ampule also contains 18.9 mg sodium chloride, 18.3 mg sodium citrate, 0.58 mg sodium hydroxide, 11.7 mg 1 N hydrochloric acid, and water for injection. Sodium hydroxide and hydrochloric acid may be added to adjust pH between 6.0 and 7.2.

Treprostinil is (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1Hbenz[f]inden-5-yl]oxy]acetic acid. Treprostinil has a molecular weight of 390.51 and a molecular formula of C₂₃H₃₄O₅.

The structural formula of treprostinil is:

Last reviewed on RxList: 4/6/2011
This monograph has been modified to include the generic and brand name in many instances.