Brand Names: Cotazym, Cotazym-S, Creon 10, Creon 20, Creon 5, Dygase, Kutrase, Ku-Zyme, Ku-Zyme HP, Lapase, Lipram, Palcaps 10, Pancrease MT 10, Pancrease MT 16, Pancrease MT 20, Pancrease MT 4, Pancrecarb MS-16, Pancrecarb MS-4, Pancrecarb MS-8, Panocaps, Panocaps MT 16, Panokase, Ultrase, Ultrase MT 12, Ultrase MT 18, Ultrase MT 20, Viokase, Viokase 16, Viokase 8

Generic Name: pancrelipase (oral) (Pronunciation: pan kre LYE pace)

• What is pancrelipase (Ultrase MT)?
• What are the possible side effects of pancrelipase?
• What is the most important information I should know about pancrelipase?
• What should I discuss with my healthcare provider before taking pancrelipase?
• How should I take pancrelipase?
• What happens if I miss a dose?
• What happens if I overdose?
• What should I avoid while taking pancrelipase?
• What other drugs will affect pancrelipase?
• Where can I get more information?

What is pancrelipase (Ultrase MT)?

Pancrelipase is a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.

Pancrelipase is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.

Pancrelipase may also be used following surgical removal of the pancreas.

Pancrelipase may also be used for other purposes not listed in this medication guide.

Cotazym

green, imprinted with ORGANON, 381

Creon 10

brown/clear, imprinted with SOLVAY, 1210

Lipram

white, imprinted with 0115, 7035

Lipram-CR10

dark brown/light brown, imprinted with 0115, 7036

Pancrease

white, imprinted with Pancrease, McNEIL

Ultrase MT 20

gray/yellow, imprinted with ULTRASE, MT 20

What are the possible side effects of pancrelipase?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

• nausea or vomiting;
• stomach pain or upset;
• diarrhea or constipation;
• greasy stools;
• rectal irritation; or
• bloating or gas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pancrelipase?

You should not take pancrelipase if you are allergic to pork proteins.

Before taking pancrelipase, tell your doctor if you have a sudden onset of pancreatitis, or worsening of chronic pancreatic disease.

It is important to use pancrelipase regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not hold the tablets or capsule contents in your mouth. The medication may irritate the inside of your mouth.

Do not inhale the powder from a pancrelipase capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

If you miss a dose of this medicine, skip the missed dose and wait until your next scheduled dose to take the medicine. Do not take extra medicine to make up the missed dose.