Ultravate Ointment (Halobetasol Propionate Ointment) Drug Information: Clinical Pharmacology

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May 27, 2012

Ultravate Ointment

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Ultravate Ointment

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CLINICAL PHARMACOLOGY

Like other topical corticosteroids,halobetasol propionate has anti-inflammatory,antipruritic and vasoconstrictive actions.The mechanism of the anti-inflammatory activity of the topical corticosteroids,in general,is unclear.However,corticosteroids are thought to act by the induction of phospholipase A₂ inhibitory proteins,collectively called lipocortins.It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however,occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption.

Human and animal studies indicate that less than 6% of the applied dose of halobetasol propionate enters the circulation within 96 hours following topical administration of the ointment.

Studies performed with Ultravate Ointment (halobetasol propionate ointment) indicate that it is in the super-high range of potency as compared with other topical corticosteroids.

Last reviewed on RxList: 7/21/2008
This monograph has been modified to include the generic and brand name in many instances.