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Uniretic

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Uniretic

Uniretic®
(moexipril HCl / hydrochlorothiazide) Tablets 7.5 mg/12.5 mg 15 mg/12.5 mg 15 mg/25 mg

WARNING

FETAL TOXICITY

See full prescribing information for complete boxed warning.

  • When pregnancy is detected, discontinue uniretic ® as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity

DRUG DESCRIPTION

Uniretic® (moexipril hydrochloride/hydrochlorothiazide) is a combination of an angiotensinconverting enzyme (ACE) inhibitor, moexipril hydrochloride, and a diuretic, hydrochlorothiazide. Moexipril hydrochloride is a fine white to off-white powder. It is soluble (about 10% weight-tovolume) in distilled water at room temperature. It has the empirical formula C27H34N2O7·HCl and a molecular weight of 535.04. It is chemically described as [3S-[2[R*(R*)],3R*]]-2-[2-[[1(Ethoxycarbonyl)-3-phenyl-propyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3isoquino-linecarboxylic acid, monohydrochloride. Moexipril hydrochloride is a non-sulfhydryl containing precursor of the active ACE inhibitor moexiprilat and its structural formula is:

Moexipril hydrochloride Structural Formula Illustration

Hydrochlorothiazide is a white, or practically white, crystalline powder. It is slightly soluble in water, freely soluble in sodium hydroxide solution, in n-butylamine and in dimethylformamide. Hydrochlorothiazide has the empirical formula C7H8CIN3O4S2 and a molecular weight of 297.75. It is chemically described as 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-,1,1dioxide. Hydrochlorothiazide is a thiazide diuretic and its structural formula is:

Hydrochlorothiazide Structural Formula Illustration

Uniretic® is available for oral administration in three tablet strengths. The inactive ingredients in all strengths are lactose, magnesium oxide, crospovidone, magnesium stearate and gelatin. The film coating in all strengths contains hydroxypropyl cellulose, hypromellose, polyethylene glycol 6000, magnesium stearate and titanium dioxide. In addition, the film coating for uniretic® 7.5 mg / 12.5 mg and uniretic® 15 mg / 25 mg contains ferric oxide.

What are the possible side effects of hydrochlorothiazide and moexipril (Uniretic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • dry mouth, thirst, nausea,...

Read All Potential Side Effects and See Pictures of Uniretic »

What are the precautions when taking moexipril hcl hydrochlorothiazide tablets (Uniretic)?

Before taking this product, tell your doctor or pharmacist if you are allergic to either moexipril or hydrochlorothiazide; or to other ACE inhibitors (e.g., captopril, lisinopril); or to other thiazides (e.g., chlorothiazide); or if you have any other allergies (including an allergic reaction after exposure to certain membranes used for blood filtering). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a history of an allergic reaction that included swelling of the face/lips/tongue/throat (angioedema), an inability to make...

Read All Potential Precautions of Uniretic »

Last reviewed on RxList: 9/24/2012
This monograph has been modified to include the generic and brand name in many instances.

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Uniretic - User Reviews

Uniretic User Reviews

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