May 26, 2017
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Uniretic Patient Information Including Side Effects

Brand Names: Uniretic

Generic Name: hydrochlorothiazide and moexipril (Pronunciation: hye droe klor oh THY a zide and moe EX a pril)

What is hydrochlorothiazide and moexipril (Uniretic)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Moexipril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Moexipril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and moexipril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and moexipril may also be used for purposes not listed in this medication guide.

HCTZ-Moexipril 12.5 mg-15 mg-COB

peanut, white, imprinted with K U, 720

HCTZ-Moexipril 12.5 mg-15 mg-TEV

oblong, white, imprinted with 9 3, 5214

HCTZ-Moexipril 12.5 mg-7.5 mg-COB

peanut, yellow, imprinted with K U, 712

HCTZ-Moexipril 12.5 mg-7.5 mg-TEV

oblong, yellow, imprinted with 9 3, 5213

HCTZ-Moexipril 25 mg-15 mg-COB

peanut, orange, imprinted with K U, 725

HCTZ-Moexipril 25 mg-15 mg-TEV

oblong, yellow, imprinted with 9 3, 5215

Uniretic 12.5 mg-15 mg

oval, white, imprinted with 720, S P

Uniretic 12.5 mg-7.5 mg

oval, yellow, imprinted with 712, S P

Uniretic 25 mg-15 mg

oval, yellow, imprinted with 725, S P

What are the possible side effects of hydrochlorothiazide and moexipril (Uniretic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • dry mouth, thirst, nausea, vomiting;
  • feeling weak, drowsy, restless, or light-headed;
  • a red, blistering, peeling skin rash;
  • jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • swelling, weight gain, feeling short of breath; or
  • fever, chills, body aches, flu symptoms.

Less serious side effects may include:

  • cough;
  • dizziness, headache, tired feeling;
  • muscle or back pain;
  • runny nose;
  • sleep problems (insomnia);
  • diarrhea, constipation, upset stomach; or
  • mild skin rash, increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Uniretic (moexipril hcl hydrochlorothiazide tablets) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about hydrochlorothiazide and moexipril (Uniretic)?

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and moexipril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, glaucoma, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Moexipril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and moexipril without telling your doctor if you are pregnant or planning a pregnancy.

Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and moexipril, unless your doctor has told you to.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and moexipril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Side Effects Centers

Uniretic - User Reviews

Uniretic User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Uniretic sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get tips on handling your hypertension.