"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
The procedure is already available in Europe and "...
(moexipril hydrochloride) Tablets
See full prescribing information for complete boxed warning.
- When pregnancy is detected, discontinue univasc ® as soon as possible.
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity
univasc® (moexipril hydrochloride), the
hydrochloride salt of moexipril, has the empirical formula C2 7H34N2
O7•HCl and a molecular weight of 535.04. It is chemically
described as [3S[2 [R*(R*)],3R*]]-2 -[2 -[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2
,3,4tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, monohydrochloride.
It is a nonsulfhydryl containing precursor of the active angiotensin-converting
enzyme (ACE) inhibitor moexiprilat and its structural formula is:
Moexipril hydrochloride is a fine white to off-white powder. It is soluble (about 10% weight-tovolume) in distilled water at room temperature.
univasc® is supplied as scored, coated tablets containing 7.5 mg and 15 mg of moexipril hydrochloride for oral administration. In addition to the active ingredient, moexipril hydrochloride, the tablet core contains the following inactive ingredients: lactose, magnesium oxide, crospovidone, magnesium stearate and gelatin. The film coating contains hydroxypropyl cellulose, hypromellose, polyethylene glycol 6000, magnesium stearate, titanium dioxide, and ferric oxide.
What are the possible side effects of moexipril (Univasc)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- feeling light-headed, fainting;
- urinating more or less than usual, or not at all;
- fever, chills, body aches, flu symptoms;
- tired feeling, muscle weakness, and pounding or uneven heartbeats;
- chest pain;
- swelling, rapid weight gain; or
- jaundice (yellowing of the skin or...
What are the precautions when taking moexipril (Univasc)?
Before taking moexipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (e.g., benazepril, captopril); or if you have any other allergies (including an allergic reaction after exposure to certain membranes used for blood filtering). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high...
Last reviewed on RxList: 2/10/2012
This monograph has been modified to include the generic and brand name in many instances.
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