Uroxatral (Alfuzosin HCl) Drug Information: Overdosage and Contraindications

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May 27, 2012

Uroxatral

Benign Prostatic Hyperplasia »

What is the prostate gland?

The prostate is a small organ about the size of a walnut. It lies below the bladder (where urine is stored) and surrounds the urethra (the tube that carries urine from the bladder). The prostate makes a fluid that helps to nourish sperm as part of the semen (ejaculatory fluid).

Prostate problems are common in men 50 and older. Most can be treated successfully without harming sexual function. A urologist is a specialist in diseases of the urinary system, including diagnosing and treating problems of the prostate gland.

How does the doctor detect prostate enlargement?

A doctor usually can detect an enlarged prostate by rectal exam. The doctor also may examine the urethra, prostate, and bladder using a cytoscope, an instrument that is inserted through the penis.

What is benign prostatic hyperplasia?

Benign prostatic hyperplasia is nonmalignant...

Read the Benign Prostatic Hyperplasia article »

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OVERDOSE

Should overdose of UROXATRAL (alfuzosin hcl) lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then the administration of intravenous fluids should be considered. If necessary, vasopressors should then be used, and the renal function should be monitored and supported as needed. Alfuzosin is 82% to 90% protein bound; therefore, dialysis may not be of benefit.

CONTRAINDICATIONS

UROXATRAL (alfuzosin hcl) is contraindicated for use in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C), since alfuzosin blood levels are increased in these patients. [see CLINICAL PHARMACOLOGY].

UROXATRAL (alfuzosin hcl) is contraindicated for use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since alfuzosin blood levels are increased. [see CLINICAL PHARMACOLOGY].

UROXATRAL (alfuzosin hcl) is contraindicated in patients known to be hypersensitive to alfuzosin hydrochloride or any component of UROXATRAL (alfuzosin hcl) tablets.

Last reviewed on RxList: 5/3/2010
This monograph has been modified to include the generic and brand name in many instances.