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Uroxatral

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Uroxatral

Uroxatral

OVERDOSE

Should overdose of UROXATRAL (alfuzosin hcl) lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then the administration of intravenous fluids should be considered. If necessary, vasopressors should then be used, and the renal function should be monitored and supported as needed. Alfuzosin is 82% to 90% protein bound; therefore, dialysis may not be of benefit.

CONTRAINDICATIONS

UROXATRAL (alfuzosin hcl) is contraindicated for use in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C), since alfuzosin blood levels are increased in these patients. [see CLINICAL PHARMACOLOGY].

UROXATRAL (alfuzosin hcl) is contraindicated for use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since alfuzosin blood levels are increased. [see CLINICAL PHARMACOLOGY].

UROXATRAL (alfuzosin hcl) is contraindicated in patients known to be hypersensitive to alfuzosin hydrochloride or any component of UROXATRAL (alfuzosin hcl) tablets.

Last reviewed on RxList: 5/3/2010
This monograph has been modified to include the generic and brand name in many instances.

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