May 28, 2016
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Uvadex

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Uvadex

UVADEX®
(methoxsalen) Sterile Solution, 20 mcg/mL




CAUTION: READ THE THERAKOS® UVAR XTS® or THERAKOS® CELLEX® PHOTOPHERESIS SYSTEM OPERATOR'S MANUAL PRIOR TO PRESCRIBING OR DISPENSING THIS MEDICATION.

UVADEX® (methoxsalen) Sterile Solution should be used only by physicians who have special competence in the diagnosis and treatment of cutaneous T-cell lymphoma and who have special training and experience in the THERAKOS® UVAR XTS® or THERAKOS® CELLEX® Photopheresis System. Please consult the appropriate Operator's Manual before using this product.

DRUG DESCRIPTION

Methoxsalen is a naturallyx occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant. It belongs to a group of compounds known as psoralens or furocoumarins. The chemical name of methoxsalen is 9-methoxy-7H-furo[3,2-g][1]-benzopyran-7-one; it has the following structure:

Each mL of UVADEX® (methoxsalen, 8-methoxypsoralen) Sterile Solution contains methoxsalen 20 mcg, propylene glycol 50 mg, sodium chloride 8 mg, sodium acetate 1.75 mg, ethanol 40.550 mg, glacial acetic acid 1.260 mg, and Water for Injection q.s. to 1.0 mL. Glacial acetic acid and sodium hydroxide are used to adjust the pH of the solution if necessary. UVADEX® is a clear, colorless to pale yellow liquid.

UVADEX® is used in combination with the THERAKOS® UVAR XTS® and THERAKOS® CELLEX® Photopheresis Systems to extracorporeally treat leukocyte enriched buffy coat.

UVADEX® (Methoxsalen) Structural Formula Illustration

What are the precautions when taking methoxsalen (Uvadex)?

Before using methoxsalen, tell your doctor or pharmacist if you are allergic to it; or to sunlight; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: unusual or bad reaction to other psoralen products in the past, conditions that make you sensitive to light (e.g., lupus, certain porphyrias, xeroderma pigmentosum, albinism), no natural lens in the eye.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: coal tar/UVA treatment, radiation treatment, arsenic...

Read All Potential Precautions of Uvadex »

Last reviewed on RxList: 4/19/2016
This monograph has been modified to include the generic and brand name in many instances.

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