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home > drugs a-z list > valstar (valrubicin) drug center > valstar (valrubicin) drug - overdosage and contraindications
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Valstar
What is the bladder?
The urinary bladder, or the bladder, is a hollow organ present in the pelvis. Most of it lies behind the pubic bone of the pelvis but when full it can extend up into the lower part of the abdomen. Its primary function is to store urine that drains into it from the kidney through tube-like structures called the ureters. The ureters from both the kidneys open into the urinary bladder. The bladder forms a low-pressure reservoir which gradually stretches out as urine fills into it. In males, the prostate gland is located adjacent to the base of the bladder where urethra joins the bladder. From time to time, the muscular wall of the bladder contracts to expel urine through the urinary passage (urethra) into the outside world.
What are the layers of the bladder?
The bladder consists of three layers of tissue. The innermost layer of the bladder which comes into contact with the urine stored inside the bl...
Valstar
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OVERDOSE
There is no known antidote for overdoses of VALSTAR (valrubicin) . The primary anticipated complications of overdosage associated with intravesical administration would be consistent with irritable bladder symptoms.
Myelosuppression is possible if VALSTAR (valrubicin) is inadvertently administered systemically or if significant systemic exposure occurs following intravesical administration (e.g., in patients with bladder rupture/perforation). The maximum tolerated dose in humans by either intraperitoneal or intravenous administration is 600 mg/m². Dose limiting toxicities are leukopenia and neutropenia, beginning within 1 week of dose administration, with nadirs by the second week, and recovery generally by the third week. If VALSTAR (valrubicin) is administered when bladder rupture or perforation is suspected, weekly monitoring of complete blood counts should be performed for 3 weeks.
CONTRAINDICATIONS
VALSTAR (valrubicin) is contraindicated in patients with known hypersensitivity to anthracyclines or polyoxyl castor oil.
Patients with concurrent urinary tract infections should not receive VALSTAR (valrubicin) .
VALSTAR (valrubicin) should not be administered to patients with a small bladder capacity, i.e., unable to tolerate a 75 mL instillation.
Last reviewed on RxList: 11/24/2008
This monograph has been modified to include the generic and brand name in many instances.
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