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Vaprisol

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VAPRISOL®
(conivaptan hydrochloride) Injection, for Intravenous Use

DRUG DESCRIPTION

Conivaptan hydrochloride is chemically [1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride, having a molecular weight of 535.04 and molecular formula C32H26N4O2•HCl. The structural formula of conivaptan hydrochloride is:

VAPRISOL®(conivaptan hydrochloride) Structural Formula Illustration

Conivaptan hydrochloride is a white to off-white or pale orange-white powder that is very slightly soluble in water (0.15 mg/mL at 23° C). Conivaptan hydrochloride injection is supplied as a sterile premixed solution with dextrose in a flexible plastic container.

Each container contains a clear, colorless, sterile, non-pyrogenic solution of conivaptan hydrochloride in dextrose. Each 100 mL, single-use premixed INTRAVIA Container contains 20 mg of conivaptan hydrochloride and 5 g of Dextrose Hydrous, USP. Lactic Acid, USP is added for pH adjustment to pH 3.4 to 3.8. The flexible plastic container is fabricated from a specially designed multilayer plastic (PL 2408). Solutions in contact with the plastic container leach out certain of the chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. The flexible container has a foil overwrap. Water can permeate the plastic into the overwrap, but the amount is insufficient to significantly affect the premixed solution.

What are the possible side effects of conivaptan (Vaprisol)?

Tell your doctor or nurse right away if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or nurse if you have any of these other serious side effects:

  • pain, redness, or swelling where the IV needle is placed;
  • irregular heartbeats;
  • confusion, extreme thirst;
  • vomiting, diarrhea;
  • feeling light-headed, fainting;
  • swelling, rapid weight gain; or
  • pain or burning when...

Read All Potential Side Effects and See Pictures of Vaprisol »

Last reviewed on RxList: 6/28/2010
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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