Recommended Topic Related To:

Vaprisol

"The U.S. Food and Drug Administration today approved Zontivity (vorapaxar) tablets to reduce the risk of heart attack, stroke, cardiovascular death, and need for procedures to restore the blood flow to the heart in patients with a previous heart "...

Vaprisol

Overdosage
Contraindications

OVERDOSE

Although no data on overdosage in humans are available, VAPRISOL has been administered as a 20 mg loading dose on Day 1 followed by continuous infusion of 80 mg/day for 4 days in hyponatremia patients and up to 120 mg/day for 2 days in CHF patients. No new toxicities were identified at these higher doses, but adverse events related to the pharmacologic activity of VAPRISOL, e.g. hypotension and thirst, occurred more frequently at these higher doses.

In case of overdose, based on expected exaggerated pharmacological activity, symptomatic treatment with frequent monitoring of vital signs and close observation of the patient is recommended.

CONTRAINDICATIONS

Hypovolemic Hyponatremia

VAPRISOL is contraindicated in patients with hypovolemic hyponatremia.

Coadministration with Potent CYP3A Inhibitors

The coadministration of VAPRISOL with potent CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritonavir, and indinavir, is contraindicated [see DRUG INTERACTIONS].

Anuric Patients

In patients unable to make urine, no benefit can be expected [see CLINICAL PHARMACOLOGY].

Known Allergy to Corn or Corn Products

Solutions containing dextrose are contraindicated in patients with known allergy to corn or corn products.

Last reviewed on RxList: 2/28/2012
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Heart Health

Get the latest treatment options.