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Although no data on overdosage in humans are available, VAPRISOL has been administered as a 20 mg loading dose on Day 1 followed by continuous infusion of 80 mg/day for 4 days in hyponatremia patients and up to 120 mg/day for 2 days in CHF patients. No new toxicities were identified at these higher doses, but adverse events related to the pharmacologic activity of VAPRISOL, e.g. hypotension and thirst, occurred more frequently at these higher doses.

In case of overdose, based on expected exaggerated pharmacological activity, symptomatic treatment with frequent monitoring of vital signs and close observation of the patient is recommended.


Hypovolemic Hyponatremia

VAPRISOL is contraindicated in patients with hypovolemic hyponatremia.

Coadministration with Potent CYP3A Inhibitors

The coadministration of VAPRISOL with potent CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritonavir, and indinavir, is contraindicated [see DRUG INTERACTIONS].

Anuric Patients

In patients unable to make urine, no benefit can be expected [see CLINICAL PHARMACOLOGY].

Known Allergy to Corn or Corn Products

Solutions containing dextrose are contraindicated in patients with known allergy to corn or corn products.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/28/2012


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