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VASCOR (bepridil hydrochloride) is a calcium channel blocker that has well characterized anti-anginal properties and known but poorly characterized type 1 anti-arrhythmic and anti-hypertensive properties. It has inhibitory effects on both the slow calcium and fast sodium inward currents in myocardial and vascular smooth muscle, interferes with calcium binding to calmodulin, and blocks both voltage and receptor operated calcium channels. It is not related chemically to other calcium channel blockers such as diltiazem hydrochloride, nifedipine and verapamil hydrochloride.
Bepridil hydrochloride monohydrate is a white to off-white, crystalline powder with a bitter taste. It is slightly soluble in water, very soluble in ethanol, methanol and chloroform, and freely soluble in acetone. The molecular weight of bepridil hydrochloride monohydrate is 421.02. Its molecular formula is C 24 H 34 N 2 O¬·HCl¬·H 2 O.
(±)-(beta)-[(2-Methylpropoxy)methyl]-N-phenyl- N -(phenyl- methyl)-1-pyrrolidineethanamine monohydrochloride monohydrate
VASCOR (bepridil) is available as film-coated tablets for oral use containing 200, 300, or 400 mg of bepridil hydrochloride monohydrate. Inactive ingredients: hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, silicon dioxide, pregelatinized corn starch, corn starch, titanium dioxide, FD&C Blue #1.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Vascor Information
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