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In this Article

• What is gadofosveset trisodium (Vasovist)?
• What are the possible side effects of gadofosveset trisodium (Vasovist)?
• What is the most important information I should know about gadofosveset trisodium (Vasovist)?
• What should I discuss with my health care provider before receiving gadofosveset trisodium (Vasovist)?
• How is gadofosveset trisodium given (Vasovist)?
• What happens if I miss a dose (Vasovist)?
• What happens if I overdose (Vasovist)?
• What should I avoid after receiving gadofosveset trisodium (Vasovist)?
• What other drugs will affect gadofosveset trisodium (Vasovist)?
• Where can I get more information?

What should I discuss with my health care provider before receiving gadofosveset trisodium (Vasovist)?

Gadofosveset trisodium can cause a life-threatening condition in people with advanced kidney disease who are undergoing an MRI. The symptoms of this condition include:

• burning, itching, swelling, and tightening or hardening of your skin;
• muscle weakness;
• pain or stiffness in your arms, hands, legs, or feet;
• deep bone pain in your ribs or your hips;
• yellow patches on the whites of your eyes; or
• skin redness or discoloration.

Before receiving this medication, tell your doctor if you have kidney disease. You may not be able to receive an MRI with gadofosveset trisodium.

Before receiving gadofosveset trisodium, tell your doctor if you have ever had any type of reaction to another contrast agent, or if you have:

• a heart rhythm disorder;
• a personal or family history of "Long QT Syndrome";
• liver disease;
• asthma, hay fever, or a history of food or drug allergies; or
• if you are on dialysis.

If you have any of these conditions, you may not be able to receive gadofosveset trisodium, or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you receive gadofosveset trisodium, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether gadofosveset trisodium passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is gadofosveset trisodium given (Vasovist)?

Gadofosveset trisodium is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting during your MRA.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.