June 30, 2015
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Vazculep

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Vazculep

VAZCULEP
(phenylephrine hydrochloride) Injection

DRUG DESCRIPTION

Phenylephrine is an alpha-1 adrenergic receptor agonist. VAZCULEP (phenylephrine hydrochloride) Injection, 10 mg/mL is a sterile, nonpyrogenic solution for intravenous use. It must be diluted before administration as an intravenous bolus or continuous intravenous infusion. The chemical name of phenylephrine hydrochloride is (-)-m-hydroxy-a- [(methylamino)methyl]benzyl alcohol hydrochloride, and its structural formula is depicted below:

VAZCULEP (phenylephrine hydrochloride) Structural Formula Illustration

Phenylephrine hydrochloride is soluble in water and ethanol, and insoluble in chloroform and ethyl ether. VAZCULEP (phenylephrine hydrochloride) Injection, 10 mg/mL is sensitive to light. Each mL contains: phenylephrine hydrochloride 10 mg, sodium chloride 3.5 mg, sodium citrate dihydrate 4 mg, citric acid monohydrate 1 mg, and sodium metabisulfite 2 mg in water for injection. The pH is adjusted with sodium hydroxide and/or hydrochloric acid if necessary. The pH range is 3.5-5.5.

Last reviewed on RxList: 7/10/2014
This monograph has been modified to include the generic and brand name in many instances.

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