IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

PANITUMUMAB - INJECTION

(pan-i-TOOM-ue-mab)

COMMON BRAND NAME(S): Vectibix

WARNING: Panitumumab has caused very serious skin reactions, which can sometimes lead to serious infections. Tell your doctor immediately if you develop any signs of a skin reaction, including acne, mild rash/itching, warmth/redness/swelling of the skin (including around the nails), dry/flaking skin, or skin sores (especially with pus). Seek immediate medical attention if you develop any signs of a serious infection (e.g., sepsis), including fever, fast heartbeat, mental/mood changes (e.g., confusion), or change in the amount of urine.

Rarely, panitumumab has caused very serious infusion reactions, including an allergic reaction. Seek immediate medical attention if you develop fever, chills, or symptoms of an allergic reaction (see Side Effects section).

USES: This medication is used alone to treat a certain type of cancer of the colon/rectum (cancer that expresses epidermal growth factor receptor-EGFR) that has spread to other parts of the body. It is used in patients who have not responded to other cancer chemotherapy treatment (e.g., fluorouracil, irinotecan, oxaliplatin). It works by slowing or stopping the growth of cancer cells.

HOW TO USE: This medication is given by injection into a vein by a health care professional. It is usually given every 14 days or as directed by your doctor. Dosage is based on your weight and response to treatment.