"A novel option is now available for patients with multiple myeloma who have tried at least three other drug therapies ― the first monoclonal antibody for use in this disease, daratumumab (Darzalex, Janssen Pharmaceuticals, Inc), has "...
Velcade Patient Information Including Side Effects
Brand Names: Velcade
Generic Name: bortezomib (Pronunciation: bor TEZ oh mib)
- What is bortezomib (Velcade)?
- What are the possible side effects of bortezomib (Velcade)?
- What is the most important information I should know about bortezomib (Velcade)?
- What should I discuss with my healthcare provider before receiving bortezomib (Velcade)?
- How is bortezomib given (Velcade)?
- What happens if I miss a dose (Velcade)?
- What happens if I overdose (Velcade)?
- What should I avoid while receiving bortezomib (Velcade)?
- What other drugs will affect bortezomib (Velcade)?
- Where can I get more information?
What is bortezomib (Velcade)?
Bortezomib interferes with the growth of some cancer cells and keeps them from spreading in your body.
Bortezomib is used to treat multiple myeloma and mantle cell lymphoma.
Bortezomib is sometimes given after other cancer medications have been tried without successful treatment.
Bortezomib may also be used for purposes not listed in this medication guide.
What are the possible side effects of bortezomib (Velcade)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Bortezomib may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
Also call your doctor at once if you have:
- new or worsening nerve problems such as numbness, burning, pain, weakness, or tingly feeling;
- a light-headed feeling, like you might pass out;
- dry cough and trouble breathing;
- severe headache, confusion, and/or seizure (convulsions);
- bloody or tarry stools, vomit that looks like blood or coffee grounds;
- severe constipation;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- fever, chills, body aches, flu symptoms;
- red bumps, spreading skin rash, painful skin lesions on your arms, face, or neck;
- feeling short of breath, even with mild exertion;
- fast or slow heart rate, weak pulse, lower back pain, blood in your urine;
- urinating less than usual or not at all;
- muscle weakness, tightness, or contraction, overactive reflexes; or
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- mild nausea, vomiting, upset stomach;
- diarrhea, constipation, bloating;
- headache, mild dizziness;
- muscle pain, bone or joint pain;
- sleep problems (insomnia);
- mild rash or itching; or
- skin irritation where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the Velcade (bortezomib) Side Effects Center for a complete guide to possible side effects
What is the most important information I should know about bortezomib (Velcade)?
Do not use bortezomib if you are pregnant. It could harm the unborn baby.
Bortezomib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
Avoid becoming dehydrated if you have any vomiting or diarrhea. Symptoms of dehydration include dizziness, dry mouth, fainting, or hot and dry skin. Talk with your doctor about how best to keep yourself hydrated.
This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
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