"The National Institutes of Health is looking for volunteers to take part in a study to compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treatin"...
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ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN PURITY, STRENGTH (E.G., U-40, U-100), MANUFACTURER, TYPE (E.G., LENTEâ â NPH, REGULAR) OR SPECIES (BEEF, PORK, BEEF/PORK, HUMAN) MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE. ADJUSTMENT MAY BE NEEDED WITH THE FIRST DOSE OR OVER A PERIOD OF SEVERAL WEEKS. BE AWARE THAT SYMPTOMS OF HYPOGLYCEMIA (LOW BLOOD GLUCOSE) OR HYPERGLYCEMIA (HIGH BLOOD GLUCOSE) MAY INDICATE THE NEED FOR DOSAGE ADJUSTMENT. PLEASE READ SECTIONS ENTITLED "INSULIN REACTION" AND "DIABETIC KETOACIDOSIS AND COMA". VELOSULIN (insulin human) BR SHOULD NOT BE MIXED WITH ANY OTHER INSULIN SINCE THE BUFFERING AGENT IN VELOSULIN (insulin human) BR MAY INTERACT WITH THE OTHER INSULIN AND RESULT IN A CHANGE OF ACTIVITY. CHANGE THE CATHETER TUBING, THE INSULIN, AND THE RESERVOIR EVERY 48 HOURS.
Insulin reaction (too little sugar in the blood, also called hypoglycemia) can occur if the external infusion pump delivers too much insulin, if you take too large an insulin bolus, skip meals, exercise or work harder than normal. Hypoglycemia can also happen if you combine insulin therapy and other medications that lower blood glucose, such as oral antidiabetic agents or other prescription and over-the-counter drugs. The symptoms, which usually come on suddenly, are hunger, dizziness, and sweating. Personality change or confusion may also occur. If you drink or eat something right away (a glass of milk or orange juice, or several sugar candies), you can often stop the progression of symptoms. If symptoms persist, call a physician; an insulin reaction can lead to unconsciousness. If a reaction results in loss of consciousness, emergency medical care should be obtained immediately. If you have had repeated reactions or if an insulin reaction has led to a loss of consciousness, contact your physician. Severe hypoglycemia can result in temporary or permanent impairment of brain function and death.
In certain cases, the nature and intensity of the warning symptoms of hypoglycemia may change. A few patients have reported that after being transferred to human insulin, the early warning symptoms of hypoglycemia were less pronounced than they had been with animal-source insulin.
DIABETIC KETOACIDOSIS AND COMA
Diabetic ketoacidosis may develop if your body has too little insulin. The most common causes are acute illness, infection, failure to take enough insulin by injection, or catheter clogging when used with an external insulin infusion pump. If you are ill, you should check your urine for ketones. The symptoms of diabetic ketoacidosis usually
USAGE IN PREGNANCY
It is particularly important to maintain good control of your diabetes during pregnancy and special attention must be paid to your diet, exercise and insulin regimens. If you are pregnant or nursing a baby, consult your physician or diabetes educator.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
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