Venofer (Iron Sucrose Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Venofer®
(iron sucrose) Injection, USP

DRUG DESCRIPTION

Venofer (iron sucrose injection, USP), an iron replacement product, is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Iron sucrose injection has a molecular weight of approximately 34,000 to 60,000 daltons and a proposed structural formula:

[Na₂Fe₅O₈(OH) ·3(H₂O)]n ·m(C₁₂H₂₂O₁₁)

where: n is the degree of iron polymerization and m is the number of sucrose molecules associated with the iron (Ill)-hydroxide.

Each mL contains 20 mg elemental iron as iron sucrose in water for injection. Venofer is available in 10 mL single use vials (200 mg elemental iron per 10 mL), 5 mL single use vials (100 mg elemental iron per 5 mL), and 2.5 mL single use vials (50 mg elemental iron per 2.5 mL). The drug product contains approximately 30% sucrose w/v (300 mg/mL) and has a pH of 10.5 to 11.1. The product contains no preservatives. The osmolarity of the injection is 1,250 mOsmol/L.

What are the possible side effects of iron sucrose injection (Venofer)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have a serious side effect such as:

chest pain;
feeling like you might pass out;
swelling in your hands, ankles, or feet;
trouble breathing; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion,...

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What are the precautions when taking iron sucrose injection (Venofer)?

Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

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Last reviewed on RxList: 8/8/2011
This monograph has been modified to include the generic and brand name in many instances.