Ventolin Syrup (Albuterol Sulfate Syrup) Drug Information: Overdosage and Contraindications

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May 27, 2012

Ventolin Syrup

Chronic Obstructive Pulmonary Disease »

What is COPD?

Chronic obstructive pulmonary disease (COPD) is comprised primarily of three related conditions - chronic bronchitis, chronic asthma, and emphysema. In each condition there is chronic obstruction of the flow of air through the airways and out of the lungs, and the obstruction generally is permanent and may be progressive over time.

While asthma features obstruction to the flow of air out of the lungs, usually, the obstruction is reversible. Between "attacks" of asthma the flow of air through the airways typically is normal. These patients do not have COPD. However, if asthma is left untreated, the chronic inflammation associated with this disease can cause the airway obstruction to become fixed. That is, between attacks, the asthmatic patient may then have abnormal air flow. This process is referred to as lung remodeling. These asthma patients with a fixed component of airway obstruction are also considered to have COPD.

Often patien...

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

The expected symptoms with overdosage are those of excessive beta-adrenergic stimulation and/or occurrence or exaggeration of any of the symptoms listed under ADVERSE REACTIONS, eg, angina, hypertension, tachycardia with rates up to 200 beats per minute, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, and insomnia. In addition, seizures, hypotension, arrhythmias, malaise, and hypokalemia may also occur. As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of VENTOLIN Syrup (albuterol sulfate syrup) . Treatment consists of discontinuation of VENTOLIN Syrup (albuterol sulfate syrup) together with appropriate symptomatic therapy. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial for overdosage of VENTOLIN Syrup (albuterol sulfate syrup) .

The oral median lethal dose of albuterol sulfate in mice is greater than 2000 mg/kg (approximately 250 times the maximum recommended daily oral dose for adults on an mg/m² basis and approximately 200 times the maximum recommended daily oral dose for children on an mg/m² basis). In mature rats, the subcutaneous (sc) median lethal dose of albuterol sulfate is approximately 450 mg/kg (approximately 110 times the maximum recommended daily oral dose for adults on an mg/m² basis and approximately 90 times the maximum recommended daily oral dose for children on an mg/m² basis). In small young rats, the sc median lethal dose is approximately 2000 mg/kg (approximately 510 times the maximum recommended daily oral dose for adults on an mg/m² basis and approximately 400 times the maximum recommended daily oral dose for children on an mg/m² basis).