home > drugs a-z list > veramyst (fluticasone furoate) drug center > veramyst (fluticasone furoate) drug - overdosage and contraindications

Recommended Topic Related To:

Veramyst

Allergy facts

  • Allergy involves an exaggerated response of the immune system.
  • The immune system is the body's organized defense mechanism against foreign invaders, particularly infections.
  • Allergens are substances that are foreign to the body and can cause an allergic reaction.
  • IgE is the allergy antibody.
  • Allergies can develop at any age.
  • Your risk of developing allergies is related to your parents' allergy history.

Introduction

In this review you will learn how allergy relates to the immune system. You will begin understanding how and why certain people become allergic. The most common allergic diseases are discussed briefly in this article.

What does an allergy mean?

An allergy refers to an exaggerated reaction by our immune system in response to bodily contact with certain foreign substances. It is exaggerated because these f...

Veramyst

font size

OVERDOSE

Chronic overdosage may result in signs/symptoms of hypercorticism [see WARNINGS AND PRECAUTIONS]. There are no data on the effects of acute or chronic overdosage with VERAMYST Nasal Spray. Because of low systemic bioavailability and an absence of acute drug-related systemic findings in clinical studies (with dosages of up to 440 mcg/day for 2 weeks [4 times the maximum recommended daily dose]), overdose is unlikely to require any therapy other than observation.

Intranasal administration of up to 2,640 mcg/day (24 times the recommended adult dose) of fluticasone furoate was administered to healthy human volunteers for 3 days. Single- and repeat-dose studies with orally inhaled fluticasone furoate doses of 50 to 4,000 mcg have shown decreased mean serum cortisol at doses of 500 mcg or higher. The oral median lethal dose in mice and rats was > 2,000 mg/kg (approximately 74,000 and 147,000 times, respectively, the maximum recommended daily intranasal dose in adults and 52,000 and 105,000 times, respectively, the maximum recommended daily intranasal dose in children, on a mcg/m² basis).

Acute overdosage with the intranasal dosage form is unlikely since 1 bottle of VERAMYST Nasal Spray contains approximately 3 mg of fluticasone furoate, and the bioavailability of fluticasone furoate is < 1% for 2.64 mg/day given intranasally and 1% for 2 mg/day given as an oral solution.

CONTRAINDICATIONS

VERAMYST Nasal Spray is contraindicated in patients with hypersensitivity to any of its ingredients [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 9/26/2011
This monograph has been modified to include the generic and brand name in many instances.

Veramyst - User Reviews

Veramyst User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Veramyst sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Allergies & Asthma

Improve treatments & prevent attacks.