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Verelan® PM (verapamil hydrochloride extended-release capsules) for oral use is indicated for the management of essential hypertension.
DOSAGE AND ADMINISTRATION
THE CONTENTS OF THE Verelan PM CAPSULE SHOULD NOT BE CRUSHED OR CHEWED. Verelan PM CAPSULES ARE TO BE SWALLOWED WHOLE OR THE ENTIRE CONTENTS OF THE CAPSULE SPRINKLED ONTO APPLESAUCE.
Administer Verelan PM once daily at bedtime. Clinical trials studied doses of 100 mg, 200 mg, 300 mg and 400 mg. The usual daily dose of extended-release Verelan PM in clinical trials has been 200 mg given by mouth once daily at bedtime. In rare instances, initial doses of 100 mg a day may be warranted in patients who have an increased response to verapamil [e.g. patients with impaired renal function, impaired hepatic function, elderly, low-weight patients, etc. (see Use In Specific Populations)]. Base upward titration on therapeutic efficacy and safety evaluated approximately 24 hours after dosing. The antihypertensive effects of Verelan PM are evident within the first week of therapy.
If an adequate response is not obtained with 200 mg of Verelan PM, the dose may be titrated upward in the following manner:
- 300 mg each evening
- 400 mg each evening (2 × 200 mg)
When Verelan PM is administered at bedtime, office evaluation of blood pressure during morning and early afternoon hours is essentially a measure of peak effect. The usual evaluation of trough effect, which sometimes might be needed to evaluate the appropriateness of any given dose of Verelan PM, would be just prior to bedtime.
Sprinkling the Capsule Contents on Food
Verelan PM capsules may also be administered by carefully opening the capsule and sprinkling the pellets onto one tablespoonful of applesauce. Swallow the applesauce immediately without chewing and follow with a glass of cool water to ensure complete swallowing of the pellets. The applesauce used should not be hot, and it should be soft enough to be swallowed without chewing. Use any pellet/applesauce mixture immediately and do not store for future use. Absorption of the pellets sprinkled onto other foods has not been tested. This method of administration may be beneficial for patients who have difficulty swallowing whole capsules. Subdividing the contents of a Verelan PM capsule is not recommended.
Dosage forms and Strengths
Extended-release capsules controlled onset: 100 mg, 200 mg, 300 mg.
100 mg: white opaque cap imprinted SCHWARZ/4085 and amethyst body imprinted 100 mg.
200 mg: amethyst opaque cap imprinted SCHWARZ/4086 and amethyst body imprinted 200 mg.
300 mg: lavender opaque cap imprinted SCHWARZ/4087 and amethyst body imprinted 300 mg.
Storage And Handling
Verelan PM (verapamil hydrochloride) extended-release pellet filled capsules are supplied in three dosage strengths:
100 mg: Two piece size 2 hard gelatin capsule, white opaque cap imprinted SCHWARZ/4085 and amethyst body imprinted with 100 mg. Product identification printed in black ink, supplied as follows: NDC 0091-4085-01 Bottle of 100s
200 mg: Two piece size 0 hard gelatin capsule, amethyst opaque cap imprinted SCHWARZ/4086 and amethyst body imprinted with 200 mg. Product identification printed in black ink, supplied as follows: NDC 0091-4086-01 Bottle of 100s
300 mg: Two piece size 00 hard gelatin capsule, lavender opaque cap imprinted SCHWARZ/4087 and amethyst body imprinted 300 mg. Product identification printed in black ink, supplied as follows: NDC 0091-4087-01 Bottle of 100s
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). [See USP Controlled Room Temperature]. Protect from moisture. Dispense in tight, light-resistant container as defined in USP.
Manufactured for: Schwarz Pharma, LLC, a Subsidiary of UCB, Inc. Smyrna, GA 30080 by: Elan Holdings, Inc. Gainesville, GA 30504, USA. Revised: 10/2011
Last reviewed on RxList: 11/23/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Verelan PM Information
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