Vermox
How to Report an Adverse Reaction to a Medication »
"Potential drug treatments are tested on paper, in laboratories and eventually in thousands of people. But every drug that goes through this cycle – every drug that FDA approves – carries some risk. One of the first lines of defense against "...
Read the How to Report an Adverse Reaction to a Medication article »
Vermox
Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
WARNINGS
There is no evidence that VERMOX® (mebendazole), even at high doses, is effective for hydatid disease. There have been rare reports of neutropenia and liver function elevations, including hepatitis, when VERMOX® (mebendazole) is taken for prolonged periods and at dosages substantially above those recommended.
PRECAUTIONS
Carcinogenesis and Mutagenesis
In carcinogenicity tests of mebendazole in mice and rats, no carcinogenic effects were seen at doses as high as 40 mg/kg given daily over two years. Dominant lethal mutation tests in mice showed no mutagenicity at single doses as high as 640 mg/kg. Neither the spermatocyte test, the F1 translocation test, nor the Ames test indicated mutagenic properties.
Impairment of Fertility
Doses up to 40 mg/kg in mice, given to males for 60 days and to females for 14 days prior to gestation, had no effect upon fetuses and offspring, though there was slight maternal toxicity.
Use in Pregnancy
Pregnancy Category C. Mebendazole has shown embryotoxic and teratogenic activity in pregnant rats at single oral doses as low as 10 mg/kg. In view of these findings the use of VERMOX® (mebendazole) is not recommended in pregnant women. In humans, a post-marketing survey has been done of a limited number of women who inadvertently had consumed VERMOX® (mebendazole) during the first trimester of pregnancy. The incidence of spontaneous abortion and malformation did not exceed that in the general population. In 170 deliveries on term, no teratogenic risk of VERMOX® (mebendazole) was identified. During pregnancy, especially during the first trimester, VERMOX® (mebendazole) should be used only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers
It is not known whether VERMOX® (mebendazole) is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when VERMOX® (mebendazole) is administered to a nursing woman.
Pediatric Use
The drug has not been extensively studied in children under two years; therefore, in the treatment of children under two years the relative benefit/ risk should be considered.
Last reviewed on RxList: 5/13/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Vermox Information
Vermox - User Reviews
Vermox User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Vermox sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.
Updated & New
