VESIcare (Solifenacin Succinate) Drug Information: Overdosage and Contraindications

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May 27, 2012

VESIcare

Overactive Bladder »

What is an overactive bladder?

An overactive bladder is a condition that results from sudden, involuntary contraction of the muscle in the wall of the urinary bladder. Overactive bladder causes a sudden and unstoppable need to urinate (urinary urgency), even though the bladder may only contain a small amount of urine.

Overactive bladder is also referred to as urge incontinence and is a form of urinary incontinence (unintentional loss of urine). Another common type of urinary incontinence is called stress incontinence, which is caused by anatomic weakness in the structures that prevent the bladder from leaking. In general, urinary incontinence is more common in women compared to men.

Although it can happen at any age, overactive bladder is especially common in older adults. Overactive bladder affects an estimated one in 11 adults in the United States. Overactive bladder, however, should not be considered a normal part of aging.

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Read the Overactive Bladder article »

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VESIcare

Urinary Incontinence in Women Slideshow Pictures

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OVERDOSE

Overdosage with VESIcare (solifenacin succinate) can potentially result in severe anticholinergic effects and should be treated accordingly. The highest dose ingested in an accidental overdose of solifenacin succinate was 280 mg in a 5-hour period. This case was associated with mental status changes. Some cases reported a decrease in the level of consciousness.

Intolerable anticholinergic side effects (fixed and dilated pupils, blurred vision, failure of heel-to-toe exam, tremors and dry skin) occurred on day 3 in normal volunteers taking 50 mg daily (5 times the maximum recommended therapeutic dose) and resolved within 7 days following discontinuation of drug.

In the event of overdose with VESIcare (solifenacin succinate) , treat with gastric lavage and appropriate supportive measures. ECG monitoring is also recommended.

CONTRAINDICATIONS

VESIcare (solifenacin succinate) is contraindicated in patients with:

urinary retention [see WARNINGS AND PRECAUTIONS],
gastric retention [see WARNINGS AND PRECAUTIONS],
uncontrolled narrow-angle glaucoma [see WARNINGS AND PRECAUTIONS], and
in patients who have demonstrated hypersensitivity to the drug [see ADVERSE REACTIONS].

Last reviewed on RxList: 5/18/2011
This monograph has been modified to include the generic and brand name in many instances.