Overdosage with VESIcare can potentially result in severe anticholinergic effects and should be treated accordingly. The highest dose ingested in an accidental overdose of solifenacin succinate was 280 mg in a 5-hour period. This case was associated with mental status changes. Some cases reported a decrease in the level of consciousness.
Intolerable anticholinergic side effects (fixed and dilated pupils, blurred vision, failure of heel-to-toe exam, tremors and dry skin) occurred on day 3 in normal volunteers taking 50 mg daily (5 times the maximum recommended therapeutic dose) and resolved within 7 days following discontinuation of drug.
VESIcare is contraindicated in patients with:
- urinary retention [see WARNINGS AND PRECAUTIONS],
- gastric retention [see WARNINGS AND PRECAUTIONS],
- uncontrolled narrow-angle glaucoma [see WARNINGS AND PRECAUTIONS], and
- in patients who have demonstrated hypersensitivity to the drug [see ADVERSE REACTIONS].
Last reviewed on RxList: 4/15/2013
This monograph has been modified to include the generic and brand name in many instances.
Additional VESIcare Information
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