May 26, 2017
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(voriconazole) Solution for Intravenous Infusion


VFEND® (voriconazole), an azole antifungal agent is available as a lyophilized powder for solution for intravenous infusion. The structural formula is:

VFEND® (voriconazole) Structural Formula Illustration

Voriconazole is designated chemically as (2R,3S)-2-(2, 4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)- 1-(1H-1,2,4-triazol-1-yl)-2-butanol with an empirical formula of C16H14F3N5O and a molecular weight of 349.3.

Voriconazole drug substance is a white to light-colored powder.

VFEND I.V. is a white lyophilized powder containing nominally 200 mg voriconazole and 3200 mg sulfobutyl ether beta-cyclodextrin sodium in a 30 mL Type I clear glass vial.

VFEND I.V. is intended for administration by intravenous infusion. It is a single-dose, unpreserved product. Vials containing 200 mg lyophilized voriconazole are intended for reconstitution with Water for Injection to produce a solution containing 10 mg/mL VFEND and 160 mg/mL of sulfobutyl ether beta-cyclodextrin sodium. The resultant solution is further diluted prior to administration as an intravenous infusion [see DOSAGE AND ADMINISTRATION].

What are the possible side effects of voriconazole (VFEND)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • sudden behavior changes, problems with thinking or speech;
  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • bone pain, swelling;
  • uneven heart rate, chest pain, general ill feeling;...

Read All Potential Side Effects and See Pictures of Vfend »

What are the precautions when taking voriconazole (Vfend)?

Before taking voriconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (e.g., itraconazole, ketoconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, recent chemotherapy, certain hereditary problems with digesting/absorbing the sugar galactose (e.g., galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption), untreated electrolyte imbalance (e.g., low calcium levels), heart problems (e.g., irregular heartbeat, cardiomyopathy).

Voriconazole may cause a condition...

Read All Potential Precautions of Vfend »

Last reviewed on RxList: 1/10/2017
This monograph has been modified to include the generic and brand name in many instances.

Vfend - User Reviews

Vfend User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Vfend sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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