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(voriconazole) IV Injection, Tablets, Liquid
Read the Patient Information that comes with VFEND before you start taking it and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your condition or treatment.
What is VFEND?
VFEND is a prescription medicine used to treat certain serious fungal infections in your blood and body. These infections are called “aspergillosis,” “esophageal candidiasis,” “Scedosporium,” “Fusarium,” and “candidemia”.
It is not known if VFEND is safe and effective in children younger than 12 years old.
Who should not take VFEND?
Do not take VFEND if you:
- are allergic to voriconazole or any of the ingredients in VFEND. See the end of this leaflet for a complete list of ingredients in VFEND.
- are taking any of the following medicines:
- cisapride (Propulsid®)
- pimozide (Orap®)
- quinidine (like Quinaglute®)
- sirolimus (Rapamune®)
- rifampin (Rifadin®)
- carbamazepine (Tegretol®)
- long-acting barbiturates like phenobarbital (Luminal®)
- efavirenz (Sustiva®)
- ritonavir (Norvir®)
- rifabutin (Mycobutin®)
- ergotamine, dihydroergotamine (ergot alkaloids)
- St. John's Wort (herbal supplement)
Ask your healthcare provider or pharmacist if you are not sure if you are taking any of the medicines listed above.
Do not start taking a new medicine without talking to your healthcare provider or pharmacist.
What should I tell my healthcare provider before taking VFEND?
Before you take VFEND, tell your healthcare provider if you:
- have or ever had heart disease, or an abnormal heart rate or rhythm. Your healthcare provider may order a test to check your heart (EKG) before starting VFEND.
- have liver or kidney problems. Your healthcare provider may do blood tests to make sure you can take VFEND.
- have trouble digesting dairy products, lactose (milk sugar), or regular table sugar. VFEND tablets contain lactose. VFEND liquid contains sucrose (table sugar).
- are pregnant or plan to become pregnant. VFEND can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking VFEND.
- are breast-feeding or plan to breast-feed. It is not known if VFEND passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take VFEND.
Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.
VFEND may affect the way other medicines work, and other medicines may affect how VFEND works.
Know what medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.
How should I take VFEND?
- VFEND may be prescribed to you as:
- VFEND I.V. (intravenous infusion) or
- VFEND tablets or
- VFEND oral suspension
- VFEND I.V. will be given to you by a healthcare provider over 1 to 2 hours.
- Take VFEND tablets or oral suspension exactly as your healthcare provider tells you to.
- Take VFEND tablets or oral suspension at least 1 hour before or at least 1 hour after meals.
VFEND oral suspension will be mixed for you by your pharmacist. Do not mix VFEND oral suspension with any other medicine, flavored liquid, or syrup.
- If you take too much VFEND, call your healthcare provider or go to the nearest hospital emergency room.
What should I avoid while taking VFEND?
- You should not drive at night while taking VFEND. VFEND can cause changes in your vision such as blurring or sensitivity to light.
- Do not drive or operate machinery, or do other dangerous activities until you know how VFEND affects you.
- Avoid direct sunlight. VFEND can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your healthcare provider if you get sunburn.
What are possible side effects of VFEND?
VFEND may cause serious side effects including:
- liver problems. Symptoms of liver problems may
- itchy skin
- yellowing of your eyes
- feeling very tired
- flu-like symptoms
- nausea or vomiting
- vision changes. Symptoms of vision changes may
- blurred vision
- changes in the way you see colors
- sensitivity to light (photophobia)
- serious heart problems. VFEND may cause changes in your heart rate or rhythm, including your heart stopping (cardiac arrest). 40
- allergic reactions. Symptoms of an allergic
reaction may include:
- feels like your heart is beating fast (tachycardia)
- chest tightness
- trouble breathing
- feel faint
- skin rash
- kidney problems. VFEND may cause new or worse problems with kidney function, including kidney failure. Your healthcare provider should check your kidney function while you are taking VFEND. Your healthcare provider will decide if you can keep taking VFEND
- serious skin reactions. Symptoms of serious
skin reactions may include:
- rash or hives
- mouth sores
- blistering or peeling of your skin
- trouble swallowing or breathing
Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.
The most common side effects of VFEND include:
- vision changes
- fast heart beat (tachycardia)
- hallucinations (seeing or hearing things that are not there)
- abnormal liver function tests
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of VFEND. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store VFEND?
- Store VFEND tablets and liquid at room temperature, 59o to 86o F (15° to 30°C). Do not refrigerate or freeze.
- VFEND suspension should be thrown away (discarded) after 14 days.
- Keep VFEND tablets and oral suspension in a tightly closed container.
- Safely throw away medicine that is out of date or no longer needed.
- Keep VFEND, as well as all other medicines, out of the reach of children.
General information about the safe and effective use of VFEND
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use VFEND for a condition for which it was not prescribed. Do not give VFEND to other people, even if they have the same symptoms that you have. It may harm them.
This Patient Information leaflet summarizes the most important information about VFEND. If you would like more information, talk to your healthcare provider. You can ask your healthcare provider or pharmacist for information about VFEND that is written for health professionals.
This product's label may have been updated. For current full prescribing information, please visit www.pfizer.com.
What are the ingredients of VFEND?
Active ingredient: voriconazole
VFEND IV: sulfobutyl ether beta-cyclodextrin sodium
VFEND tablets: lactose monohydrate, pregelatinized starch, croscarmellose sodium, povidone, magnesium stearate, and a coating containing hypromellose, titanium dioxide, lactose monohydrate, and triacetin
VFEND oral suspension: colloidal silicon dioxide, titanium dioxide, xanthan gum, sodium citrate dihydrate, sodium benzoate, anhydrous citric acid, natural orange flavor, and sucrose
Last reviewed on RxList: 2/17/2015
This monograph has been modified to include the generic and brand name in many instances.
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