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Vibramycin IV Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Vibramycin I.V. (doxycycline hyclate) is a tetracycline antibiotic used to treat many different bacterial infections such as urinary tract infections acne gonorrhea and chlamydia periodontitis (gum disease) and others. The brand name Vibramycin I.V. has been discontinued in the U.S. Generic versions may be available. Common side effects of Vibramycin I.V. (doxycycline hyclate) include:
- stomach upset
- loss of appetite
- skin rash
- vaginal itching or discharge. or
- rectal discomfort.
The usual dosage of Vibramycin I.V. is 200 mg on the first day of treatment administered in one or two infusions. Subsequent daily dosage is 100 to 200 mg depending upon the severity of infection with 200 mg administered in one or two infusions. Vibramycin may interact with anti-seizure medications retinoids digoxin live bacterial vaccines penicillins phenobarbital warfarin and hormonal birth control. Tell your doctor all medications and supplements you use and all vaccines you recently received. Vibramycin is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss birth control. If this medication is used to treat a life-threatening infection and treatment options are limited discuss the risks and benefits with your doctor. This drug passes into breast milk in very small amounts. While there have been no reports of harm to nursing infants consult your doctor before breastfeeding.
Our Vibramycin (doxycycline hyclate) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Vibramycin IV Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have serious side effects such as: sunburn-like skin reaction (sun sensitivity), unusual change in the amount of urine, unusual tiredness, redness/swelling/pain at the injection site, weakness, hearing changes (e.g., ringing in the ears, decreased hearing), easy bruising/bleeding, new signs of infection (e.g., persistent sore throat, fever, chills), stomach/abdominal pain, persistent nausea/vomiting.
Tetracycline drugs such as doxycycline may rarely cause a serious increase in pressure inside the skull (intracranial hypertension-IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after doxycycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: persistent/severe headache, vision changes (such as blurred/double vision, decreased vision, sudden blindness), persistent nausea/vomiting.
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
A very serious allergic reaction to this drug is rare. However, get medical help right away. if you notice any of the following symptoms of a serious allergic reaction, including: rash, skin sores/blisters, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, new or worsening swelling/pain in the joints, chest pain, fast/irregular heartbeat.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Vibramycin IV (Doxycycline hyclate)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Vibramycin IV FDA Prescribing Information: Side Effects
Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported rarely. These reactions have been caused by both the oral and parenteral administration of tetracyclines.
Immune: Hypersensitivity reactions including urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, pericarditis, exacerbation of systemic lupus erythematosus, and drug rash with eosinophilia and systemic symptoms (DRESS).
Bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving full therapeutic dosages. These conditions disappeared rapidly when the drug was discontinued.
Read the entire FDA prescribing information for Vibramycin IV (Doxycycline hyclate)
Additional Vibramycin Intravenous Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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