Vidaza (Azacitidine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Vidaza

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VIDAZA
(azacitidine for injection) for SC or IV Use

DRUG DESCRIPTION

VIDAZA (azacitidine for injection) contains azacitidine, which is a pyrimidine nucleoside analog of cytidine. Azacitidine is 4-amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one. The structural formula is as follows:

VIDAZA (azacitidine) Structural Formula Illustration

The empirical formula is C₈H₁₂N₄O₅. The molecular weight is 244. Azacitidine is a white to off-white solid. Azacitidine was found to be insoluble in acetone, ethanol, and methyl ethyl ketone; slightly soluble in ethanol/water (50/50), propylene glycol, and polyethylene glycol; sparingly soluble in water, water saturated octanol, 5% dextrose in water, N-methyl-2-pyrrolidone, normal saline and 5% Tween 80 in water; and soluble in dimethylsulfoxide (DMSO).

The finished product is supplied in a sterile form for reconstitution as a suspension for subcutaneous injection or reconstitution as a solution with further dilution for intravenous infusion. Vials of VIDAZA contain 100 mg of azacitidine and 100 mg mannitol as a sterile lyophilized powder.

What are the possible side effects of azacitidine (Vidaza)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;
pain, itching, burning,...

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What are the precautions when taking azacitidine (Vidaza)?

Before using azacitidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as mannitol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver cancer.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Wash your...

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Last reviewed on RxList: 2/7/2012
This monograph has been modified to include the generic and brand name in many instances.