Videx
HIV and AIDS: Antiretroviral Drugs, Treatments and Medications »
"Entry Inhibitors (including Fusion Inhibitors) and CCR5 Co-receptor Antagonist
Entry Inhibitors
Entry inhibitors block HIV entry into CD4+ cells.
Fusion inhibitors
The only drug in this class "...
Read the HIV and AIDS: Antiretroviral Drugs, Treatments and Medications article »
Videx
OVERDOSE
There is no known antidote for VIDEX (didanosine) overdosage. In phase 1 studies, in which VIDEX was initially administered at doses ten times the currently recommended dose, toxicities included: pancreatitis, peripheral neuropathy, diarrhea, hyperuricemia, and hepatic dysfunction. Didanosine is not dialyzable by peritoneal dialysis, although there is some clearance by hemodialysis [see CLINICAL PHARMACOLOGY].
CONTRAINDICATIONS
These recommendations are based on either drug interaction studies or observed clinical toxicities.
Allopurinol
Coadministration of didanosine and allopurinol is contraindicated because systemic exposures of didanosine are increased, which may increase didanosine-associated toxicity [see CLINICAL PHARMACOLOGY].
Ribavirin
Coadministration of didanosine and ribavirin is contraindicated because exposures of the active metabolite of didanosine (dideoxyadenosine 5'-triphosphate) are increased. Fatal hepatic failure, as well as peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis have been reported in patients receiving both didanosine and ribavirin.
Last reviewed on RxList: 12/6/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Videx Information
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