home > drugs a-z list > vigiv (vaccinia immune globulin intravenous) drug center > vigiv (vaccinia immune globulin intravenous) drug - overdosage and contraindications

Consequences of an overdose are not known.

While Vaccinia Immune Globulin Intravenous (Human) (VIGIV (vaccinia immune globulin intravenous) ) should be considered in treatment of severe ocular complications due to vaccinia virus, VIGIV (vaccinia immune globulin intravenous) is contraindicated for use in the presence of isolated vaccinia keratitis. VIGIV (vaccinia immune globulin intravenous) should not be used in individuals with a history of anaphylaxis or prior severe systemic reaction associated with the parenteral administration of this or other human immunoglobulin preparations.^{7, 8, 9} VIGIV (vaccinia immune globulin intravenous) contains trace amounts of IgA. While CNJ-016™ contains less than 40 μg/mL IgA, persons with selective IgA deficiency can develop antibodies to IgA and therefore could have anaphylactic reactions to subsequent administration of blood products that contain IgA, including VIGIV (vaccinia immune globulin intravenous) .

REFERENCES

7. Immune globulin intravenous (human) Iveegam En IGIV. In: Physician's Desk Reference. 55th Ed. Montvale, New Jersey: Medical Economics Company, Inc; 2001:816-820.

8. Immune globulin intravenous (human) (IGIV) Gammagard® S/D. In: Physician's Desk Reference. 58th ed. Montvale, New Jersey: Medical Economics Company, Inc.; 2004:816-819.

9. Cytogam®, cytomegalovirus immune globulin intravenous (human) (CMV-IGIV). In: Physician's Desk Reference. 58th ed. Montvale, New Jersey: Medical Economics Company, Inc.; 2004:1907-1909.

Last reviewed on RxList: 3/5/2009
This monograph has been modified to include the generic and brand name in many instances.